同义词：   2,5-Dihydroxy-3-(1-methylindol-3-yl)-6-phenyl-1,4-benzoquinone  

应用；   A potent and selective activator of IRTK  

分子量:   345.35  

分子式:   C₂₁H₁₅NO₄  

* Refer to Certificate of Analysis for lot specific data (including water content).

介绍 技术信息 安全信息 安全技术说明书和分析证明书

IRTK Activator is a potent and highly selective activator of insulin receptor tyrosine kinase (IRTK, EC₅₀ = 300 nM in CHO cells expressing human insulin receptor). It does not activate other closely related receptors such as epidermal growth factor receptor (EGFR), insulin-like growth factor receptor (IGFIR), and platelet-derived growth factor receptor (PDGFR) at concentrations up to 30 μM.

参考文献

1. Qureshi, S A., et al., 2000. Activation of insulin signal transduction pathway and anti-diabetic activity of small molecule insulin receptor activators. The Journal of biological chemistry. 275(47): 36590-5. PMID: 10967116
2. Liu, K., et al., 2000. Discovery of a potent, highly selective, and orally efficacious small-molecule activator of the insulin receptor. Journal of medicinal chemistry. 43(19): 3487-94. PMID: 11000003

外观 :

Powder

物理状态 :

Solid

溶解度 :

Soluble in DMSO (10 mg/ml).

保存 :

Store at -20° C

熔点 :

267-269° C

沸点 :

630.43° C at 760 mmHg (Predicted)

密度 :

1.35 g/cm    ³ (Predicted)

折射率 :

n    ²⁰    _D 1.68 (Predicted)

IC50 :

IRTK: EC    ₅₀50 = 300 nM (CHO cells)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.  

PubChem CID :

9819548

MDL 号码 :

MFCD03452691

SMILES :

CN1C=C(C2=CC=CC=C21)C3=C(C(=O)C(=C(C3=O)O)C4=CC=CC=C4)O