同义词：   11-keto TXB2-d4  

应用；   Used as an internal standard for the quantification of 11-dehydro TXB2 by GC- or LC-mass spectrometry  

CAS号码:   1240398-15-5  

分子量:   372.5  

分子式:   C₂₀H₂₈D₄O₆  

Supplemental Information:   This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.  

* 参考分析证明 大量特定数据 (包括水 含量).

介绍 技术信息 安全信息 安全技术说明书和分析证明书

11-dehydro Thromboxane B2-d4 contains 4 deuterium atoms at the 3, 3', 4, and 4' positions and is intended for use as an internal standard for the quantification of 11-dehydro TXB2 by GC- or LC-mass spectrometry. TXB2 is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2. 11-dehydro TXB2 is one of the main plasma metabolites of TXB2 and can be used as a marker for in vivo TXA2 synthesis.

参考文献

1 Ciabattoni, G., Pugliese, F., Davi, G., et al. Fractional conversion of thromboxane B2 to urinary 11-dehydrothromboxane B2 in man. Biochim Biophys Acta 992 66-70 (1989). 2 Fitzgerald, G.A., Lawson, J., Blair, I.A., et al. Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometry. Adv Prostaglandin Thromboxane Leukot Res 15 87-90 (1985). 3 Takasaki, W., Nakagawa, A., Tanaka, Y., et al. Enzyme immunoassay of human plasma 11-dehydrothromboxane B2. Thromb Res 63 331-341 (1991). 4 Catella, F., Healy, D., Lawson, J.A., et al. 11-dehydro Thromboxane B2: A quantitative index of thromboxane A2 formation in the human circulation. Proc Natl Acad Sci USA 83 5861-5865 (1986).

规划 :

A solution in methyl acetate

物理状态 :

Liquid

保存 :

Store at -20° C

沸点 :

57° C

仅供科研使用。不可用于诊断或治疗。  

运输 :

UN 1231, Class 3, Packing group II

PubChem CID :

24778496

SMILES :

[2H]C([2H])(CC(=O)O)C([2H])([2H])/C=C\C[C@H]1[C@H](CC(=O)O[C@@H]1/C=C/[C@H](CCCCC)O)O