同义词：   1,7-Dimethyl-1H-purine-2,6-dione-(dimethyl-d₆)  

应用；   A labeled derivative of xanthine  

CAS号码:   611-59-6 (unlabeled)  

纯度:   98 atom % D, 98% (CP)  

分子量:   186.20  

分子式:   C₇D₆H₂N₄O₂  

* 参考分析证明 大量特定数据 (包括水 含量).

介绍 技术信息 安全信息 安全技术说明书和分析证明书

1,7-Dimethylxanthine-d6 (dimethyl-d6) is a labeled form of 1,7-Dimethylxanthine also known as Paraxanthine (sc-212526), which functions as a PARP-1 inhibitor in pulmonary epithelial cells. It is known that 1,7-Dimethylxanthine-d6 (dimethyl-d6) is structurally similar to caffeine (sc-202514) and possibly mediates the physiological effects of caffeine. Studies suggest that 1,7-Dimethylxanthine-d6 (dimethyl-d6) acts as a competitive phosphodiesterase inhibitor, which increases intracellular cAMP, activates PKA, inhibits TNF-α and leukotriene synthesis. Also 1,7-Dimethylxanthine-d6 (dimethyl-d6) acts as a Na+/K+ ATPase enzymatic effector.

参考文献

1. Jiang, M., et al. 1998. Planta Med. 64: 375-377. PMID: 9619123
2. Marques, L.J., et al. 1999. Am. J. Respir. Crit. Care Med. 159: 508-511. PMID: 9927365
3. Essayan, D.M. 2001. J. Allergy Clin. Immunol. 108: 671-680. PMID: 11692087
4. Guerreiro, S., et al. 2008. Mol. Pharmacol. 74: 980-989. PMID: 18621927
5. Geraets, L., et al. 2010. Eur. J. Pharmacol. 629: 132-139. PMID: 19962977

外观 :

Crystalline

物理状态 :

Solid

溶解度 :

Soluble in water (Partly miscible), ethanol (0.6 mg/ml)(unlabeled), and 0.1N Sodium Hydroxide (2 mg/ml)(unlabeled), DMSO(unlabeled), and DMF(unlabeled).

保存 :

Store at room temperature

熔点 :

294-296° C

密度 :

1.6 g/cm    ³(unlabeled)

折射率 :

n    ²⁰    _D 1.74(unlabeled)

仅供科研使用。不可用于诊断或治疗。  

德国水公害等级 :

3

RTECS :

RV9380000(unlabeled)

MDL 号码 :

MFCD11656180

EC号码 :

210-271-9(unlabeled)

Beilstein 注册 :

197907(unlabeled)