CAS号码:   836682-32-7  

分子量:   185.34  

分子式:   C₆H₃D₈NOS₂  

* 参考分析证明 大量特定数据 (包括水 含量).

介绍 技术信息 安全信息 安全技术说明书和分析证明书

D,L-Sulforaphane-d8 is a potent, selective inducer of phase II detoxification enzymes with anti-carcinogenic properties and occurs naturally in broccoli. Found to inhibit chemically induced mammary tumor formation in rats and is an anti-tumor agent.

参考文献

Zhang, Y., et al.: Proc. Natl. Acad. Sci. USA, 89, 2399 (1992), Shikita, M., et al.: Biochem. J., 341, 725 (1999), Wittich, S., et al.: J. Med. Chem., 45, 3296 (2002), Lee, J., et al.: Cancer Lett., 224, 171 (2005),

物理状态 :

Liquid

溶解度 :

Soluble in chloroform, ethyl acetate, and DMSO (40 mg/ml)(unlabeled). Insoluble in water(unlabeled).

保存 :

Store at -20° C

熔点 :

68.93° C (Predicted)

沸点 :

368.16° C at 760 mmHg (Predicted)

密度 :

1.23 g/mL (Predicted)

折射率 :

n    ²⁰    _D 1.57 (Predicted)

IC50 :

Jurkat (Acute leukemic T-cells): IC    ₅₀ = 3.8 µM (human); Hepa-1c1c7 TAOc1Bprc1 mutant cells : IC    ₅₀ = 5.9 µM (mouse); Hepa-1c1c7 cells: IC    ₅₀ = 2.07 ug/ml (mouse); LTEP-A2 cells : IC    ₅₀ = 6.2 µM (human); Hepa-1c1c7 Bprc1 mutant cells : IC    ₅₀ = 7.6 µM (mouse); HepG2 (Hepatoblastoma cells): EC    ₅₀50 = 4 µM (human) (all for unlabeled)

pK值 :

pK    _a: -4.61 (Predicted) (unlabled)

仅供科研使用。不可用于诊断或治疗。  

德国水公害等级 :

3 (unlabeled)

RTECS :

EK4416000

PubChem CID :

11389813

默克索引 :

14: 8962 (unlabeled)

MDL 号码 :

MFCD00198068 (unlabeled)

SMILES :

[2H]C([2H])(N=C=S)C([2H])([2H])C([2H])([2H])C([2H])([2H])S(C)=O