同义词：   N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxyphenyl)acetamide  

应用；   An inhibitor shown to suppress apoptosis, caspase cleavage, and cytochrome C release  

CAS号码:   894804-07-0  

纯度:   >95%  

分子量:   356.37  

分子式:   C₁₈H₂₀N₄O₄  

* 参考分析证明 大量特定数据 (包括水 含量).

介绍 技术信息 安全信息 安全技术说明书和分析证明书

JNK inhibitor VIII is an inhibitor of c-Jun N-terminal kinases (JNK) that has been reported to suppress apoptosis, caspase cleavage, and cytochrome C release. Studies indicate that the inhibitor can block the phosphorylation of JNK without affecting the expression of IL-6, IL-8, or COX-2. JNK activity studies demonstrate that JNK Inhibitor VIII inhibits the phosphorylation of JNKAR1 and response to anisomycin (sc-3524). Additionally, JNK Inhibitor VIII has been noted to reduce TGF-induced JNK activation. JNK Inhibitor VIII is an inhibitor of JNK1, JNK2 and JNK3.

参考文献

1. Ogino, T., et al. 2009. Leuk. Res. 33: 151-158. PMID: 18718660
2. Kluwe, J., et al. 2010. Gastroenterology. 138: 347-359. PMID: 19782079
3. Turpeinen, T., et al. 2010. J. Pharmacol. Exp. Ther. 333: 310-318. PMID: 20089808
4. Fosbrink, M., et al. 2010. Proc. Natl. Acad. Sci. U.S.A. 107: 5459-5464. PMID: 20212108

物理状态 :

Solid

溶解度 :

Soluble in DMSO (100 mM).

保存 :

Store at -20° C

熔点 :

244.11° C (Predicted)

沸点 :

~658.6° C at 760 mmHg (Predicted)

密度 :

~1.3 g/cm    ³ (Predicted)

折射率 :

n    ²⁰    _D 1.60 (Predicted)

IC50 :

JNK1: IC    ₅₀ = 45 nM (human); JNK2: IC    ₅₀ = 160 nM (human); NB7: IC    ₅₀ = 2.27 µM (human); LB2241-RCC: IC    ₅₀ = 6.58 µM (human); NCI-H1299: IC    ₅₀ = 13.20 µM (human)

Ki 数据 :

JNK1: K    _i= 2 nM (human); JNK2: K    _i= 3.98 nM (human); JNK3: K    _i= 52 nM (human); Flt-1: K    _i>398.11 nM (human); c-Abl: K    _i>630.96 nM (human)

pK值 :

pK    _a: 11.23 (Predicted), pK    _b: 1.6 (Predicted)

仅供科研使用。不可用于诊断或治疗。  

PubChem CID :

11624601

MDL 号码 :

MFCD19690908

SMILES :

CCOC1=C(C(=CC(=N1)NC(=O)CC2=C(C=CC(=C2)OC)OC)N)C#N