同义词：   H-319/68  

应用；   A thrombin mutant anticoagulant antagonist  

CAS号码:   159776-70-2  

纯度:   ≥95%  

分子量:   429.51  

分子式:   C₂₂H₃₁N₅O₄  

* 参考分析证明 大量特定数据 (包括水 含量).

介绍 技术信息 安全信息 安全技术说明书和分析证明书

Melagatran is an agent which functions by preventing tissue factor expression in human platelet-monocyte heterotypic complexes. Studies indicate that Melagatran causes fibrinolytic activity in PRP clot models, which is comparable to that observed in platelet-poor models which consist of tissue factor-induced clots. In addition, these studies determined that the fibrinolysis ability of Melagatran is not affected by the presence of platelets. Melagatran effects platelet aggregation in a dose dependent manner, with low concentration having the greater effectiveness. Also it has been suggested that Melagatran can differentially inhibit γ-thrombin/PAR-4 receptors over α-thrombin/PAR-1 receptors.

参考文献

1. Semeraro, F., et al. 2007. Thromb. Haemost. 98: 1208-1214. PMID: 18064315
2. Belliard, A., et al. 2008. Cell. Mol. Biol. 54: OL1077-OL1082. PMID: 19149969
3. Soslau, G., et al. 2008. J. Thromb. Thrombolysis. 25: 198-203. PMID: 17710375

物理状态 :

Solid

溶解度 :

Soluble in Methanol

保存 :

Store at -20° C

熔点 :

172-177° C

密度 :

~1.4 g/cm    ³ (Predicted)

仅供科研使用。不可用于诊断或治疗。  

PubChem CID :

183797

SMILES :

C1CCC(CC1)[C@H](C(=O)N2CC[C@H]2C(=O)NCC3=CC=C(C=C3)C(=N)N)NCC(=O)O