同义词：   1,3,4-IP3 (sodium salt); Ins(1,3,4)-P3 (sodium salt)  

应用；   An inhibitor of Ins(3,4,5,6)-P4 kinase activity  

纯度:   >98%  

分子量:   486.04  

分子式:   C₆H₁₂O₁₅P₃•₃Na  

* 参考分析证明 大量特定数据 (包括水 含量).

介绍 技术信息 安全信息 安全技术说明书和分析证明书

D-myo-Inositol-1,3,4-triphosphate sodium salt is one of many inositol oligophosphate isomers implicated in signal transduction. Ins(1,3,4)-P3 acts through the inhibition of Ins(3,4,5,6)-P4 kinase activity to increase the cellular level of Ins(3,4,5,6)-P4 and thus inhibit calcium-activated chloride channels. The levels of Ins(1,3,4)-P3 are regulated by the levels of cytosolic free calcium. The receptor-mediated activation of phospholipase C (PLC) can be seen as the initiating event in this cascade, since PLC generates Ins(1,4,5)-P3 which releases calcium from intracellular storage reservoirs. This leads to increase in the cytosolic concentration of free calcium.

参考文献

1. Majerus, P.W. 1992. Annu. Rev. Biochem. 61: 225-250. PMID: 1323235
2. Berridge, M.J. 1993. Nature. 361: 315-325. PMID: 8381210
3 Yang, X., et al. 1999. J Biol Chem 274: 18973-18980.PMID: 10383396
4 Lew, P.D., et al. 1986. J Biol Chem. 261: 13121-13127. PMID: 3489712 5 Yoshida, Y. and Imai, S. 1997. Jpn. J. Pharmacol. 74: 125-137. PMID: 9243320

外观 :

Lyophilized powder

物理状态 :

Solid

保存 :

Store at -20° C

仅供科研使用。不可用于诊断或治疗。  

PubChem CID :

53394553

SMILES :

[P](O[C@@H]1[C@@H](O[P](O)([O-])=O)[C@H](O)[C@@H](O)[C@H](O[P](O)([O-])=O)[C@@H]1O)(O)([O-])=O.[Na+].[Na+].[Na+]