概述

• 产品名称Anti-NPM1/ALK抗体[EPR11413]

• 描述

  兔单克隆抗体[EPR11413] to NPM1/ALK

• 特异性In more than 50% of systemic Anaplastic large cell lymphoma, t(2;5)(p23;q35) translocation can be found (Falini et al., 1999; Morris et al., 2001). (PMID: 9736036 and PMID: 11380391). The corresponding genes have been cloned and represent a fusion between the NPM and the ALK genes (Morris et al., 1994). (PMID: 8122112). Encodes a chimeric 80-kDa protein consisting of the N-terminal portion (amino acids 1-117) of NPM fused to the cytoplasmic portion of ALK (amino acids 1058-1620). Reference: Galietta et al., 2007. (PMID: 17537995).

• 经测试应用IHC-P,ICC/IF

• 种属反应性

  与反应: Mouse, Rat, Human    
   

• 免疫原

  Fusion protein within Human NPM1/ALK. The exact sequence is proprietary.

      Run BLAST with      Run BLAST with    

• 阳性对照    

• Human large cell lymphoma tissue, NCI-HC228 cells

• 常规说明

  This product is a recombinant rabbit monoclonal antibody.

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

• 形式Liquid

• 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

• 存储溶液Preservative: 0.01% Sodium azide
  Constituents: 59% PBS, 40% Glycerol, 0.05% BSA

• 纯度Tissue culture supernatant

• 克隆单克隆

• 克隆编号EPR11413

• 同种型IgG

• 研究领域

• Cancer

• Oncoproteins/suppressors

• Oncoproteins

• Growth factor receptors

• Neuroscience

• Neurotransmission

• Receptors / Channels

• Tyrosine Kinase Receptors

• Tags & Cell Markers

• Cell Type Markers

• Tumor Associated

• Neuroscience

• Cell Type Marker

• Neuron marker

• Soma marker

• Neuroscience

• Neurotransmission

• Intracellular Signaling

• Kinases

Anti-NPM1/ALK antibody [EPR11413] 图像

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  Immunocytochemistry/ Immunofluorescence - Anti-NPM1/ALK antibody [EPR11413] (ab180607)          

     

  Immunocytochemical staining of paraformaldehyde fixed NCI-H2228 cells labeling ALK using ab180607 at 1/50 dilution followed by Goat anti rabbit IgG (Alexa Fluor®555) at 1/200 (red).  Cells were counterstained with DAPI (blue)

   

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  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-NPM1/ALK antibody [EPR11413] (ab180607)          

     

  Immunohistochemical staining of formalin fixed paraffin-embedded Human anaplastic large cell lymphoma labeling ALK with ab180607 at 1/4000 dilution.  HRP polymer for rabbit IgG was used as a secondary.  Sections were counterstained with Hematoxylin.