• Species Reactivity

  Rat

• Specificity

  Detects rat KOR in direct ELISAs.

• Source

  Recombinant Monoclonal Rabbit IgG Clone # 1123A

• Purification

  Protein A or G purified from cell culture supernatant

• Immunogen

  Rat KOR N-terminal synthetic peptide    
  Accession # P34975

• Formulation

  Supplied as a solution in PBS containing BSA, Glycerol and Sodium Azide. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

• Label

  Unconjugated

Applications

• Recommended    
  Concentration

  Sample

• Immunocytochemistry

  8-25 µg/mL

  See below

• 
  

Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

Data Examples

Preparation and Storage

• Shipping

  The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

• Stability & Storage

  Use a manual defrost freezer and avoid repeated freeze-thaw cycles.    

• 12 months from date of receipt, -20 °C, as supplied.

• 1 month, 2 to 8 °C under sterile conditions after opening.

• 6 months, -20 to -70 °C under sterile conditions after opening.

Background: KOR

KOR is a 45 kDa 7TM opioid receptor that is primarily expressed in the central nervous system and peripheral visceral pain sensory nerves. Following ligation by dynorphin peptides, KOR signaling induces analgesia, dysphoria, diuresis, and increased feeding desire. KOR also exerts neuroprotective and anti-inflammatory effects. Human KOR shares 94% amino acid sequence identity with mouse and rat KOR.

• Long Name:

  Kappa Opioid Receptor

• Entrez Gene IDs:

  4986 (Human); 18387 (Mouse); 29335 (Rat)

• Alternate Names:

  kappa opioid receptor; kappa-type opioid receptor; KOR; K-OR-1; KOR-1; Opiate receptor, kappa-1; opioid receptor, kappa 1; OPRK; OPRK1; Oprk2; R21