Mouse IFN-beta MAb (Clone 1176D) 100 UG

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Mouse IFN-beta MAb (Clone 1176D) 100 UG信息二维码

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  • 更新2024-11-27 05:07
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产品介绍

    基本参数

    详细说明

    • Species Reactivity

      Mouse

    • Specificity

      Detects mouse IFN‑ beta in direct ELISAs.    
       

    • Source

      Recombinant Monoclonal Rabbit IgG Clone # 1176D

    • Purification

      Protein A or G purified from cell culture supernatant

    • Immunogen

      Human embryonic kidney cell line HEK293-derived mouse IFN‑ beta    
      Ile22-Asn182    
      Accession # P01575

    • Formulation

      Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

    • Endotoxin Level

      <0.10 EU per 1 μg of the antibody by the LAL method.  

    • Label

      Unconjugated

    Applications

    • Recommended    
      Concentration

      Sample

    • Neutralization

      Measured by its ability to neutralize IFN‑ beta inhibition of viral-induced cytopathy in the L‑929 mouse fibroblast cell line. The Neutralization Dose (ND    50) is typically 0.25-1.25 µg/mL in the presence of 10 pg/mL Recombinant Mouse IFN‑ beta.

    Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

    Data Examples

    Neutralization      
         

    IFN‑ beta Inhibition of Viral-induced Cytopathy and Neutralization by Mouse IFN‑ beta Antibody.

    Recombinant Mouse IFN‑ beta (Catalog # ) reduces the viral-induced cytopathy in the L‑929 mouse fibroblast cell line in a dose-dependent manner (orange line) as measured by Resazurin (Catalog # ). Inhibition of viral activity elicited by Recombinant Mouse IFN‑ beta (10 pg/mL) is neutralized (green line) by increasing concentrations of Rabbit Anti-Mouse IFN‑ beta  Monoclonal Antibody (Catalog # MAB8234). The ND50 is typically
    0.25-1.25 µg/mL.

    Preparation and Storage

    • Reconstitution

      Reconstitute at 0.5 mg/mL in sterile PBS.

    • Shipping

      The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

    • Stability & Storage

      Use a manual defrost freezer and avoid repeated freeze-thaw cycles.    

      • 12 months from date of receipt, -20 to -70 °C as supplied.

      • 1 month, 2 to 8 °C under sterile conditions after reconstitution.

      • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

    Background: IFN-beta

    Interferon beta (IFN-beta ), also known as fibroblast IFN, is a secreted, approximately 22 kDa member of the type I interferon family of molecules (1). Mature mouse IFN-beta shares 75% and 47% amino acid sequence identity with the rat and human proteins, respectively. Fibroblasts are the major producers of IFN-beta, but it can also be produced by dendritic cells, macrophages, and endothelial cells in response to pathogens (2). It is transcriptionally regulated by TRAF3, IRF3, IRF7, and NF-kappa B (3, 4). IFN-beta -deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS) (5). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS (6-10). IFN-beta can additionally induce the expression of the anti-inflammatory cytokine IL-10 (11).

    • References:

      1. González-Navajas, J.M. et al. (2012) Nat. Rev. Immunol. 12:125.

      2. Reder, A.T. and X. Feng (2013) Front. Immunol. 4:281.

      3. Schafer, S.L. et al. (1998) J. Biol. Chem. 273:2714.

      4. Häcker, H. et al. (2006) Nature 439:204.

      5. Teige, I. et al. (2003) J. Immunol. 170:4776.

      6. Shinohara, M.L. et al. (2008) Immunity 29:68.

      7. Guo, B. et al. (2008) J. Clin. Invest. 118:1680.

      8. Ramgolam, V.S. and S. Markovic-Plese (2010) Endocr. Metab. Immune Disord. Drug Targets 10:161.

      9. Martín-Saavedra, F.M. et al. (2008) Mol. Immunol. 45:4008.

      10. Inoue, M. and M.L. Shinohara (2013) Immunology 139:11.

      11. Wang, H. et al. (2011) J. Immunol 186:675.

    • Long Name:

      Interferon beta

    • Entrez Gene IDs:

      3456 (Human); 15977 (Mouse); 24481 (Rat)

    • Alternate Names:

      Fibroblast interferon; IFBIFNB; IFF; IFNB1; IFNbeta; IFN-beta; interferon beta; interferon, beta 1, fibroblast; MGC96956







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