• Species Reactivity

  Rat

• Specificity

  Detects rat IL‑1 Rrp2/IL‑1 R6 in direct ELISAs and Western blots. In direct ELISAs, approximately 25% cross‑reactivity with recombinant human (rh) IL‑1 R6 is observed and less than 5% cross‑reactivity with rhIL-18 R beta, rhIL-1 RI, and rhIL‑1 RII is observed.

• Source

  Polyclonal Goat IgG

• Purification

  Antigen Affinity-purified

• Immunogen

  Mouse myeloma cell line NS0-derived recombinant rat IL‑1 Rrp2/IL‑1 R6    
  Gly22-Tyr340    
  Accession # Q62929

• Formulation

  Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

• Endotoxin Level

  <0.10 EU per 1 μg of the antibody by the LAL method.  

• Label

  Unconjugated

Applications

• 
  

  Recommended    
  Concentration

  Sample

• Western Blot

  0.1 µg/mL

  Recombinant Rat IL‑1 Rrp2/IL‑1 R6 Fc Chimera (Catalog # )

• 
  

Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

Preparation and Storage

• Reconstitution

  Reconstitute at 0.2 mg/mL in sterile PBS.

• Shipping

  The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

• Stability & Storage

  Use a manual defrost freezer and avoid repeated freeze-thaw cycles.    

• 12 months from date of receipt, -20 to -70 °C as supplied.

• 1 month, 2 to 8 °C under sterile conditions after reconstitution.

• 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-1 Rrp2/IL-1 R6

The Interleukin 1 receptor family comprises at least nine members. All family members possess three immunoglobulin (Ig)-like domains in their extracellular region. Most members also have an intracellular TIR (Toll-like receptor/IL-1 receptor) signaling domain that is also conserved in the Toll-like receptor family. A subtype of the IL-1 R family, SIGIRR (single Ig domain-containing IL-1 R-related molecule) differs from the other nine members by having only one Ig domain.

IL-1 Rrp2, also known as IL-1 R6, is a transmembrane protein belonging to the IL-1 receptor family. It is a ligand binding subunit that associates with IL-1 RAcP to form a functional receptor complex for IL-1F6, IL-1F8, and IL-1F9.

• Long Name:

  Interleukin 1 Receptor-like 2

• Entrez Gene IDs:

  8808 (Human); 107527 (Mouse); 171106 (Rat)

• Alternate Names:

  IL-1 R6; IL-1 Rrp2; IL1RL2; IL-1RL2; IL1Rrp2; IL-1Rrp2