• Species Reactivity

  Human

• Specificity

  Detects human STRO-1.

• Source

  Monoclonal Mouse IgM Clone # STRO-1

• Immunogen

  Human CD34    ⁺ bone marrow cells

• Formulation

  Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

• Label

  Alexa Fluor 350

Applications

• 
  

  Recommended    
  Concentration

  Sample

• Flow Cytometry

  0.25-1 µg/10    ⁶ cells

  MG‑63 human osteosarcoma cell line

• 
  

Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

Preparation and Storage

• Shipping

  The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

• Stability & Storage

  Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: STRO-1

STRO-1 is a cell surface protein expressed by bone marrow stromal cells and erythroid precursors. The frequency of colony forming units-fibroblasts (CFU-F) was enriched 100-fold in the STRO-1  ⁺/Glycophorin A  ^- population from bone marrow cells (1). The subset of marrow cells that expresses the STRO-1 antigen is capable of differentiating into multiple mesenchymal lineages including hematopoiesis-supportive stromal cells with a vascular smooth muscle-like phenotype, adipocytes, osteoblasts, and chondrocytes (2).

• References:

1. Simmons, P.J. and B. Torok-Storb (1991) Blood 78:55.

2. Dennis, J.E. et al. (2002) Cells Tissues Organs 170:73.

• Long Name:

  A Stromal Cell Precursor Surface Antigen

• Alternate Names:

  STRO1; STRO-1