Recombinant Human EphA10 Fc Chimera Protein, CF 50 UG

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Recombinant Human EphA10 Fc Chimera Protein, CF 50 UG信息二维码

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  • 更新2024-11-27 08:02
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产品介绍

    基本参数

    详细说明

    • Purity

      >90%, by SDS-PAGE under reducing conditions and visualized by silver stain

    • Endotoxin Level

      <0.10 EU per 1 μg of the protein by the LAL method.  

    • Activity

      Measured by its ability to bind biotinylated rhEphrin-A3/Fc Chimera in a functional ELISA.

    • Source

      Mouse myeloma cell line, NS0-derived

      Human EphA10
      (Glu34 - Ala565)
      Accession # NP_001092909
      IEGRMDHuman IgG1
      (Pro100 - Lys330)
      N-terminus
      C-terminus
    • Accession #

    • N-terminal Sequence    
      Analysis

      Glu34

    • Structure / Form

      Disulfide-linked homodimer

    • Predicted Molecular Mass

      84.3 kDa (monomer)

    • SDS-PAGE

      100-106 kDa, reducing conditions

    5188-EA

     

    Formulation Lyophilized from a 0.2 μm filtered solution in PBS.


    Reconstitution Reconstitute at 200 μg/mL in sterile PBS.



    Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.


    Stability & Storage:       Use a manual defrost freezer and avoid repeated freeze-thaw cycles.      

    • 12 months from date of receipt, -20 to -70 °C as supplied.

    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.

    • 3 months, -20 to -70 °C under sterile conditions after reconstitution.


    Background: EphA10

    EphA10 is a member of the transmembrane Eph receptor tyrosine kinase family. Although the A and B classes of Eph proteins have a common structural organization, they are distinguished by their preference for Ephrin ligands. Eph-Ephrin interactions are widely involved in the regulation of cell migration, tissue morphogenesis, and cancer progression (1 - 4). The 532 amino acid (aa) extracellular domain (ECD) of human EphA10 contains an N-terminal Ephrin binding region followed by two fibronectin type II domains, a 422 aa cytoplasmic domain contains the tyrosine kinase domain and a sterile alpha motif (SAM) (5). Alternate splicing generates a soluble isoform that is truncated following the Ephrin binding region, and a transmembrane isoform that lacks only the SAM (5). Within the ECD, human EphA10 shares 38% - 54% aa sequence identity with other EphA and EphB proteins. It shares 95% and 88% aa sequence identity with the ECD of mouse and rat EphA10, respectively. EphA10 is preferentially expressed in testis and is upregulated in some breast and prostate carcinoma cell lines (5 - 7). It selectivity binds Ephrin-A1, 2, 3, 4,and 5 relative to Ephrin-B1 and -B2 (5).

    • References:

      1. Pasquale, E.B. (2008) Cell 133:38.

      2. Merlos-Suarez, A. and E. Batlle (2008) Curr. Opin. Cell Biol. 20:194.

      3. Arvanitis, D. and A. Davy (2008) Genes Dev. 22:416.

      4. Robinson, D.R. et al. (2000) Oncogene 19:5548.

      5. Aasheim, H.-C. et al. (2005) Biochim. Biophys. Acta 1723:1.

      6. Fox, B.P. et al. (2006) Biochem. Biophys. Res. Commun. 342:1263.

      7. Fox, B.P. and R.P. Kandpal (2004) Biochem. Biophys. Res. Commun. 318:882.

    • Long Name:

      Eph Receptor A10

    • Entrez Gene IDs:

      284656 (Human); 298528 (Rat)

    • Alternate Names:

      EC 2.7.10.1; EPH receptor A10; EphA10; EphA10s protein; ephrin type-A receptor 10; FLJ16103; FLJ33655; MGC43817



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