详细说明
- Species ReactivityHuman
- SpecificityDetects human LAP (TGF-beta 1) in direct ELISAs. In direct ELISAs, this antibody does not cross-react with recombinant human (rh) TGF‑ beta 1, rhTGF‑ beta 2, rhTGF‑ beta 1.2, rhTGF‑ beta 3, or rhTGF‑ alpha.
- SourceMonoclonal Mouse IgG 1 Clone # 27232
- PurificationProtein A or G purified from hybridoma culture supernatant
- ImmunogenS. frugiperda insect ovarian cell line Sf 21-derived recombinant human LAP (TGF-beta 1)
Leu30-Arg278 (Cys33Ser)
Accession # P01137 - FormulationSupplied in a saline solution containing BSA and Sodium Azide.
- LabelPhycoerythrin
- Recommended
ConcentrationSample
- Flow Cytometry10 µL/10 6 cellsSee below
Flow Cytometry | Detection of LAP (TGF-beta 1) in Human Platelets by Flow Cytometry. Human CD41+ platelets were stained with Mouse Anti-Human LAP (TGF-beta 1) PE‑conjugated Monoclonal Antibody (Catalog # FAB2463P, filled histogram) or isotype control antibody (Catalog # , open histogram). View our protocol for . |
- ShippingThe product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
- Stability & StorageProtect from light. Do not freeze.
- 12 months from date of receipt, 2 to 8 °C as supplied.
The TGF‑ beta family includes several related proteins (70‑80% sequence homology) from mammalian, avian, or Xenopus systems that are now designated TGF‑ beta 1, TGF‑ beta 2, TGF‑ beta 1.2, TGF‑ beta 3, TGF‑ beta 4, and TGF‑ beta 5. These proteins are secreted by cells in the form of an inactive complex, referred to as latent TGF-beta, that consists of TGF‑ beta associated non-covalently with a Latency-associated peptide (LAP). These two proteins are synthesized as a single pro-peptide that is cleaved in a post Golgi compartment prior to secretion. Different TGF‑ beta family members are naturally associated with their own distinct LAPs.
- Long Name:Latency-associated Peptide
- Entrez Gene IDs:7040 (Human)
- Alternate Names:LAP (TGFbeta 1); LAP (TGF-beta 1)