Human Integrin alpha 1/CD49a Alexa Fluor 750 Antibody 100 UG

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Human Integrin alpha 1/CD49a Alexa Fluor 750 Antibody 100 UG信息二维码

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产品介绍

    基本参数

    详细说明

    • Species Reactivity
      Human
    • Specificity
      Detects Integrin alpha 1/CD49a in direct ELISAs.
    • Source
      Monoclonal Rabbit IgG Clone # 1090A
    • Immunogen
      Chinese hamster ovary cell line CHO derived recombinant human Integrin alpha 1 beta 1
      Met1-Pro1141 (Integrin alpha 1) & Gln21-Asp728 (Integrin beta 1)
      Accession # P56199
    • Formulation
      Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
    • Label
      Alexa Fluor 750
    Applications
    •  
      Recommended
      Concentration
      Sample
    • Flow Cytometry
      0.25-1 µg/10 6 cells
      HeLa human cervical epithelial carcinoma cell line
    Please Note: Optimal dilutions should be determined by each laboratory for each application. are available in the Technical Information section on our website.
    Preparation and Storage
    • Stability & Storage
      Store the unopened product at 2 - 8 °C. Do not use past expiration date.
    Background: Integrin alpha 1/CD49a

    Integrin alpha 1 (also VLA-1, CD49a and Laminin and Collagen Receptor) is a 190-210 kDa member of the integrin alpha chain family of molecules.  It is found on smooth muscle cells, osteoblasts, adipocytes and intestinal epithelium.  Integrin alpha 1 forms a noncovalent heterodimer with Integrin beta 1, and serves as a divalent-cation dependent receptor for collagen types I, IV, VI, XIII and XVI.  It also binds the diarrhea-associated NSP4 enterotoxin of rotavirus.  Mature human Integrin alpha 1 is a 1151 amino acid (aa) type I transmembrane glycoprotein that contains a 1113 aa extracellular domain (ECD) and a 15 aa cytoplasmic tail.  The ECD contains one vWFA/I-domain (aa 147-360) that binds collagen, plus multiple divalent cation binding sites.  Potential splice variants exist that show a two and four aa substitution for aa 765-1179.  Over aa 29-1141 (the ECD), human Integrin alpha 1 shares 88% aa identity with mouse Integrin alpha 1. 

    • Entrez Gene IDs:
      3672 (Human); 109700 (Mouse); 25118 (Rat)
    • Alternate Names:
      CD49 antigen-like family member A; CD49a antigen; CD49a; Integrin alpha 1; integrin, alpha 1; ITGA1; Laminin and collagen receptor; very late activation protein 1; VLA-1; VLA1integrin alpha-1
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