Human LILRA4/CD85g/ILT7 Alexa Fluor 647 Antibody 100 UG

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Human LILRA4/CD85g/ILT7 Alexa Fluor 647 Antibody 100 UG信息二维码

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产品介绍

    基本参数

    详细说明

    • Species Reactivity
      Human
    • Specificity
      Detects human LILRA4/CD85g/ILT7 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) LILRA5, rhILT2, 3, 4, 5, or 6 is observed.
    • Source
      Monoclonal Mouse IgG2a Clone # 656688
    • Immunogen
      Mouse myeloma cell line NS0-derived recombinant human LILRA4/CD85g/ILT7
      Glu24-Asn446
      Accession # P59901
    • Formulation
      Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
    • Label
      Alexa Fluor 647
    Applications
    •  
      Recommended
      Concentration
      Sample
    • Flow Cytometry
      0.25-1 µg/10 6 cells
      Human peripheral blood monocytes
    Please Note: Optimal dilutions should be determined by each laboratory for each application. are available in the Technical Information section on our website.
    Preparation and Storage
    • Shipping
      The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
    • Stability & Storage
      Store the unopened product at 2 - 8 °C. Do not use past expiration date.
    Background: LILRA4/CD85g/ILT7

    LILRA4, also known as ILT7 and CD85g, is a 499 amino acid (aa) type I transmembrane glycoprotein that contains four Ig-like domains in its extracellular region. LILRA4 is selectively expressed on plasmacytoid dendritic cells (pDC). It binds to BST2/CD317 on bone marrow stromal cells and associates with the gamma subunit of Fc epsilon RI. This receptor complex transmits signals that inhibit the TLR-induced production of type I interferon. The LILRA4-mediated interactions between pDC and tumor cells similarly inhibit the production of proinflammatory cytokines and contribute to reduced anti-tumor immune responses. Alternate splicing of human LILRA4 generates an isoform that lacks the N-terminal 43 aa of the extracellular domain.

    • Long Name:
      Leukocyte Immunoglobulin-like Receptor, Subfamily A (with TM domain), Member 4
    • Entrez Gene IDs:
      23547 (Human)
    • Alternate Names:
      CD85 antigen-like family member G; CD85g antigen; CD85g; ILT7; ILT-7; ILT7MGC129598; Immunoglobulin-like transcript 7; leukocyte immunoglobulin-like receptor subfamily A member 4; leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4; leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member4; LILRA4; MGC129597
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