Human TRAIL R2/TNFRSF10B Alexa Fluor 750 Antibody 100 UG

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Human TRAIL R2/TNFRSF10B Alexa Fluor 750 Antibody 100 UG信息二维码

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产品介绍

    基本参数

    详细说明

    • Species Reactivity
      Human
    • Specificity
      Detects human TRAIL R2 in direct ELISAs and Western blots. In direct ELISAs, does not cross-react with recombinant human (rh) TRAIL R1, rhTRAIL R3, rhTRAIL R4, or recombinant mouse TRAIL R2.
    • Source
      Monoclonal Mouse IgG2b Clone # 71908
    • Immunogen
      Mouse myeloma cell line NS0-derived recombinant human TRAIL R2/TNFRSF10B
      Ile56-Glu182
      Accession # O14763
    • Formulation
      Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
    • Label
      Alexa Fluor 750
    Applications
    •  
      Recommended
      Concentration
      Sample
    • Flow Cytometry
      0.25-1 µg/10 6 cells
      MDA‑MB‑231 human breast cancer cell line
    Please Note: Optimal dilutions should be determined by each laboratory for each application. are available in the Technical Information section on our website.
    Preparation and Storage
    • Shipping
      The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
    • Stability & Storage
      Store the unopened product at 2 - 8 °C. Do not use past expiration date.
    Background: TRAIL R2/TNFRSF10B

    Human TRAIL R2, also known as DR5 and TRICK 2, is a type 1, TNF R family, membrane protein which is a receptor for TRAIL (APO2 ligand). In the new TNF superfamily nomenclature, TRAIL R2 is referred to as TNFRSF10B. TRAIL R2 cDNA encodes a 440 amino acid residue precursor protein containing extracellular cysteine-rich domains, a transmembrane domain and a cytoplasmic death domain. Among TNF receptor family proteins, TRAIL R2 is most closely related to TRAIL R1/DR4, sharing 55% amino acid sequence identity. Binding of trimeric TRAIL to TRAIL R2 induces apoptosis. The induction of apoptosis likely requires oligomerization of the receptor. The human TRAIL R2/Fc chimera neutralizes the ability of TRAIL to induce apoptosis. Besides TRAIL R2, an additional TRAIL R1/DR4, which tranduces apoptosis signaling, and two TRAIL decoy receptors, which antagonize TRAIL-induced apoptosis, have been reported.

    • References:
      1. Chaudhary, P.M. et al. (1997) Immunity 7:821.
      2. Walczak, H. et al. (1997) EMBO J. 16:5386.
      3. Golstein, P. (1997) Curr. Biol. 7:R750.
    • Long Name:
      TRAIL Receptor 2
    • Entrez Gene IDs:
      8795 (Human); 21933 (Mouse)
    • Alternate Names:
      CD262 antigen; CD262; death domain containing receptor for TRAIL/Apo-2L; Death receptor 5; DR5; DR5TRICK2B; Fas-like protein; KILLER/DR5; KILLERapoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRAIL-R2apoptosis inducing receptor TRAIL-R2; TRAILR2cytotoxic TRAIL receptor-2; TRICK2; TRICK2A; TRICKB; tumor necrosis factor receptor superfamily member 10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor-like protein ZTNFR9; ZTNFR9
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