Human TRAIL R2/TNFRSF10B Alexa Fluor 750 Antibody 100 UG

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Human TRAIL R2/TNFRSF10B Alexa Fluor 750 Antibody 100 UG信息二维码

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产品介绍

    基本参数

    详细说明

    • Species Reactivity

      Human

    • Specificity

      Detects human TRAIL R2 in direct ELISAs and Western blots. In direct ELISAs, does not cross-react with recombinant human (rh) TRAIL R1, rhTRAIL R3, rhTRAIL R4, or recombinant mouse TRAIL R2.

    • Source

      Monoclonal Mouse IgG2b Clone # 71908

    • Immunogen

      Mouse myeloma cell line NS0-derived recombinant human TRAIL R2/TNFRSF10B    
      Ile56-Glu182    
      Accession # O14763

    • Formulation

      Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

    • Label

      Alexa Fluor 750

    Applications


    • Recommended    
      Concentration

      Sample

    • Flow Cytometry

      0.25-1 µg/10    6 cells

      MDA‑MB‑231 human breast cancer cell line


    Please Note: Optimal dilutions should be determined by each laboratory for each application.  are available in the Technical Information section on our website.

    Preparation and Storage

    • Shipping

      The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

    • Stability & Storage

      Store the unopened product at 2 - 8 °C. Do not use past expiration date.

    Background: TRAIL R2/TNFRSF10B

    Human TRAIL R2, also known as DR5 and TRICK 2, is a type 1, TNF R family, membrane protein which is a receptor for TRAIL (APO2 ligand). In the new TNF superfamily nomenclature, TRAIL R2 is referred to as TNFRSF10B. TRAIL R2 cDNA encodes a 440 amino acid residue precursor protein containing extracellular cysteine-rich domains, a transmembrane domain and a cytoplasmic death domain. Among TNF receptor family proteins, TRAIL R2 is most closely related to TRAIL R1/DR4, sharing 55% amino acid sequence identity. Binding of trimeric TRAIL to TRAIL R2 induces apoptosis. The induction of apoptosis likely requires oligomerization of the receptor. The human TRAIL R2/Fc chimera neutralizes the ability of TRAIL to induce apoptosis. Besides TRAIL R2, an additional TRAIL R1/DR4, which tranduces apoptosis signaling, and two TRAIL decoy receptors, which antagonize TRAIL-induced apoptosis, have been reported.

    • References:

      1. Chaudhary, P.M. et al. (1997) Immunity 7:821.

      2. Walczak, H. et al. (1997) EMBO J. 16:5386.

      3. Golstein, P. (1997) Curr. Biol. 7:R750.

    • Long Name:

      TRAIL Receptor 2

    • Entrez Gene IDs:

      8795 (Human); 21933 (Mouse)

    • Alternate Names:

      CD262 antigen; CD262; death domain containing receptor for TRAIL/Apo-2L; Death receptor 5; DR5; DR5TRICK2B; Fas-like protein; KILLER/DR5; KILLERapoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRAIL-R2apoptosis inducing receptor TRAIL-R2; TRAILR2cytotoxic TRAIL receptor-2; TRICK2; TRICK2A; TRICKB; tumor necrosis factor receptor superfamily member 10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor-like protein ZTNFR9; ZTNFR9







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