Recombinant Human TrkA Fc Chimera Protein, CF 50 UG

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Recombinant Human TrkA Fc Chimera Protein, CF 50 UG信息二维码

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3-Amino-5-methoxycarbonylphenylboronic acid, pinacol ester  1 g 2,3-Dichloro-6-(trifluoromethyl)benzyl bromide  1 g 1-(4-Fluorophenyl)-5-methoxycarbonyl-2(1H)-pyridinone  1 g N,N-Diethyl-cyclohexane-1,4-diamine  1 g N-Methyl-DL-leucine hydrochloride  5 g N-(2-Chloroethyl) 3-boronobenzamide  5 g

产品介绍

    基本参数

    详细说明

    • Purity
      >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
    • Endotoxin Level
      <0.01 EU per 1 μg of the protein by the LAL method.
    • Activity
      Measured by its ability to inhibit NGF-induced proliferation of TF‑1 human erythroleukemic cells. The ED 50 for this effect is 0.8-4 µg/mL in the presence of 10 ng/mL of rhNGF.
    • Source
      Mouse myeloma cell line, NS0-derived
      Human Trk A
      (Ala33-Glu407)
      Accession #AAA36770
      IEGRID Human IgG1
      (Pro100-Lys330)
      N-terminus C-terminus
    • Accession #
    • N-terminal Sequence
      Analysis
      Ala33
    • Structure / Form
      Disulfide-linked homodimer
    • Predicted Molecular Mass
      67.4 kDa (monomer)
    • SDS-PAGE
      115-125 kDa, reducing conditions
    175-TK
     
    Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
    Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
    Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
    Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
    • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
    Background: TrkA

    Trk A, the product of the proto-oncogene trk, is a member of the neurotrophic tyrosine kinase receptor family that has three members. Trk A, Trk B and Trk C preferentially bind NGF, NT-4 and BDNF, and NT-3, respectively. All Trk family proteins share a conserved complex subdomain organization consisting of a signal peptide, two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain. Two distinct Trk A isoforms that differ by virtue of a 6-amino acid insertion in their extracellular domain have been identified. The longer Trk A isoform is the only isoform expressed within neuronal tissues whereas the shorter Trk A is expressed mainly in non-neuronal tissues. NGF binds to Trk A with low affinity and activates its cytoplasmic kinase, initiating a signaling cascade that mediates neuronal survival and differentiation. Higher affinity binding of NGF requires the coexpression of Trk A with the p75 NGF receptor (NGFR), a member of the tumor necrosis factor receptor superfamily. NGFR binds all neurotrophins with low affinity and modulates Trk activity as well as alters the specificity of Trk receptors for their ligands. NGFR can also mediate cell death when expressed independent of Trk.

    • References:
      1. Esposito, D. et al. (2001) J. Biol. Chem. 276:32687.
      2. Sofroniew, M.V. et al. (200) Annu. Rev. Neurosci. 24:1217.
    • Long Name:
      Neurotrophic Tyrosine Kinase Receptor A
    • Entrez Gene IDs:
      4914 (Human); 59109 (Rat)
    • Alternate Names:
      DKFZp781I14186; EC 2.7.10; EC 2.7.10.1; MTChigh affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; NTRK1; NTRK-1; p140-TrkA; TRK1-transforming tyrosine kinase protein; TrkA; Trk-A; TRKAOncogene TRK; TRKTRK1; tyrosine kinase receptor A
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