Recombinant Human FCRL2/FcRH2 Protein, CF 50 UG

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Recombinant Human FCRL2/FcRH2 Protein, CF 50 UG信息二维码

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产品介绍

    基本参数

    详细说明

    • Purity
      >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
    • Endotoxin Level
      <0.01 EU per 1 μg of the protein by the LAL method.
    • Activity
      Measured by its ability to bind human IgG with an estimated K D <80 nM.
    • Source
      Mouse myeloma cell line, NS0-derived Leu20-Asp395, with a C-terminal 6-His tag
    • Accession #
    • N-terminal Sequence
      Analysis
      Leu20
    • Predicted Molecular Mass
      41.9 kDa
    • SDS-PAGE
      60-68 kDa, reducing conditions
    2048-FC
     
    Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
    Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
    Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
    Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
    • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
    Background: FCRL2/FcRH2

    Fc receptor-like 2 (FCRL2), also known as FcRH2 and IRTA4, belongs to the family of glycoprotein homologs of classical immunoglobulin (Ig) Fc receptors. In human, the type I transmembrane FCRL protein family contains from three to nine immunoglobulin-like domains (1, 2). Mature human FcRH2 consists of a 382 amino acid (aa) extracellular domain (ECD) with four Ig-like C2-set domains, a 21 aa transmembrane segment, and an 86 aa cytoplasmic domain with one ITAM-like, and two ITIM-like motifs (3 - 5). Alternate splicing of human FCRL2 may generate isoforms with N-terminal, internal, or C-terminal deletions (4, 5). The gene for FcRH2 maps to the human Iq21-23 locus which is a hotspot for chromosomal translocation events associated with B cell malignancies (3, 6). Although there are several Fc receptor-like genes in the mouse, none of these is a clear ortholog to human FCRL2 (7). FCRL proteins are differentially expressed among B cells (2). FCRL2 is preferentially expressed on naïve and CD27+ memory B cells within the spleen, lymph nodes, tonsils, and peripheral blood (3, 4, 8, 9). It is also expressed on most B cells in B cell chronic lymphocytic leukemia (B-CLL) patients (10). FCRL2 upregulation is associated with mutation of the immunoglobulin heavy chain variable (IGHV) and less aggressive forms of B-CLL (9, 11).

    • References:
      1. Maltais, L.J. et al. (2006) Nat. Immunol. 7:431.
      2. Davis, R.S. et al. (2007) Annu. Rev. Immunol. 25:525.
      3. Miller, I. et al. (2002) Blood 99:2662.
      4. Davis, R.S. et al. (2001) Proc. Natl. Acad. Sci. 98:9772.
      5. Xu, M.J. et al. (2001) Biochem. Biophys. Res. Commun. 280:768.
      6. Hatzivassiliou, G. et al. (2001) Immunity 14:277.
      7. Davis, R.S. et al. (2004) Int. Immunol. 16:1343.
      8. Polson, A.G. et al. (2006) Int. Immunol. 18:1363.
      9. Huttmann, A. et al. (2006) Leukemia 20:1774.
      10. Kazemi, T. et al. (2008) Int. J. Cancer 123:2113.
      11. Li, F.J. et al. (2008) Blood 112:179.
    • Long Name:
      Fc Receptor-like 2
    • Entrez Gene IDs:
      79368 (Human)
    • Alternate Names:
      CD307b antigen; CD307b; Fc receptor homolog 2; Fc receptor-like 2; FcRH2; FCRH2SPAP1B; FCRL2; FcR-like protein 2; IFGP family protein 4; IFGP4; Immunoglobulin receptor translocation-associated protein 4; immunoglobulin superfamily Fc receptor, gp42; IRTA4; IRTA4SPAP1C; SH2 domain containing phosphatase anchor protein 1; SH2 domain-containing phosphatase anchor protein 1Fc receptor-like protein 2; SPAP1; SPAP1A; SPAP1immune receptor translocation-associated protein 4
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