Recombinant Human ESAM Fc Chimera Protein, CF 50 UG

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Recombinant Human ESAM Fc Chimera Protein, CF 50 UG信息二维码

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产品介绍

    基本参数

    详细说明

    • Purity

      >95%, by SDS-PAGE under reducing conditions and visualized by silver stain

    • Endotoxin Level

      <0.01 EU per 1 μg of the protein by the LAL method.  

    • Activity

      Measured by its ability to induce ERK phosphorylation in BaF3 mouse pro‑B cells transfected with human ESAM. Stimulation of 2.5 x 10    5 serum-starved hESAM transfected BaF3 cells with 25 µg Recombinant Human ESAM Fc Chimera (Catalog # ) for 30 minutes at 37° C leads to ERK phosphorylation.

    • Source

      Mouse myeloma cell line, NS0-derived

      Human ESAM
      (Gln30 - Ala247)
      Accession # Q96AP7
      IEGRMDHuman IgG1
      (Pro100 - Lys330)
      N-terminus
      C-terminus
    • Accession #

    • N-terminal Sequence    
      Analysis

      No results obtained: Gln30 predicted

    • Predicted Molecular Mass

      50.3 kDa (monomer)

    • SDS-PAGE

      67-75 kDa, reducing conditions

    2688-EC

     

    Formulation Lyophilized from a 0.2 μm filtered solution in PBS.


    Reconstitution Reconstitute at 100 μg/mL in sterile PBS.



    Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.


    Stability & Storage:       Use a manual defrost freezer and avoid repeated freeze-thaw cycles.      

    • 12 months from date of receipt, -20 to -70 °C as supplied.

    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.

    • 3 months, -20 to -70 °C under sterile conditions after reconstitution.


    Background: ESAM

    Endothelial cell-selective adhesion molecule (ESAM) is a 55 kDa type I transmembrane glycoprotein that belongs to the JAM family of immunoglobulin superfamily molecules (1, 2). Human ESAM is synthesized as a 390 amino acid (aa) protein composed of a 29 aa signal peptide, a 216 aa extracellular region, a putative 26 aa transmembrane segment, and a 119 aa cytoplasmic domain. The extracellular region contains one V-type and one C2-type Ig domain and is involved in homophilic adhesion (1). In the cytoplasmic domain, there is a docking site for the multifunctional adaptor protein MAGI-1 (3). The extracellular region of human ESAM shows 90%, 74%, 69% and 67% aa identity with monkey, canine, mouse and rat extracellular ESAM, respectively. ESAM is expressed on endothelial cells, activated platelets and megakaryocytes, and can be found associated with cell-to-cell junctions. Whether ESAM is restricted to a particular junctional type is not clear (1, 2). ESAM deficient mice have no defect in vascularization but do have reduced angiogenic potential. This may be due to a decreased migratory response to FGF-2 (4).

    • References:

      1. Hirata, K-I, et al. (2001) J. Biol. Chem. 276:16223.

      2. Nasdala, I. et al. (2002) J. Biol. Chem. 277:16294.

      3. Wegmann, F. et al. (2004) Exp. Cell Res. 300:121.

      4. Ishida, T. et. al. (2003) J. Biol. Chem. 278:34598.

    • Long Name:

      Endothelial Cell Adhesion Molecule

    • Entrez Gene IDs:

      90952 (Human); 69524 (Mouse)

    • Alternate Names:

      2310008D05Rik; endothelial cell adhesion molecule; endothelial cell-selective adhesion molecule; ESAM; HUEL (C4orf1)-interacting protein; LP4791 protein; W117m






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