Recombinant Human ESAM Fc Chimera Protein, CF 50 UG

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Recombinant Human ESAM Fc Chimera Protein, CF 50 UG信息二维码

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3-Amino-5-methoxycarbonylphenylboronic acid, pinacol ester  1 g 2,3-Dichloro-6-(trifluoromethyl)benzyl bromide  1 g 1-(4-Fluorophenyl)-5-methoxycarbonyl-2(1H)-pyridinone  1 g N,N-Diethyl-cyclohexane-1,4-diamine  1 g N-Methyl-DL-leucine hydrochloride  5 g N-(2-Chloroethyl) 3-boronobenzamide  5 g

产品介绍

    基本参数

    详细说明

    • Purity
      >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
    • Endotoxin Level
      <0.01 EU per 1 μg of the protein by the LAL method.
    • Activity
      Measured by its ability to induce ERK phosphorylation in BaF3 mouse pro‑B cells transfected with human ESAM. Stimulation of 2.5 x 10 5 serum-starved hESAM transfected BaF3 cells with 25 µg Recombinant Human ESAM Fc Chimera (Catalog # ) for 30 minutes at 37° C leads to ERK phosphorylation.
    • Source
      Mouse myeloma cell line, NS0-derived
      Human ESAM
      (Gln30 - Ala247)
      Accession # Q96AP7
      IEGRMD Human IgG1
      (Pro100 - Lys330)
      N-terminus C-terminus
    • Accession #
    • N-terminal Sequence
      Analysis
      No results obtained: Gln30 predicted
    • Predicted Molecular Mass
      50.3 kDa (monomer)
    • SDS-PAGE
      67-75 kDa, reducing conditions
    2688-EC
     
    Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
    Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
    Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
    Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
    • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
    Background: ESAM

    Endothelial cell-selective adhesion molecule (ESAM) is a 55 kDa type I transmembrane glycoprotein that belongs to the JAM family of immunoglobulin superfamily molecules (1, 2). Human ESAM is synthesized as a 390 amino acid (aa) protein composed of a 29 aa signal peptide, a 216 aa extracellular region, a putative 26 aa transmembrane segment, and a 119 aa cytoplasmic domain. The extracellular region contains one V-type and one C2-type Ig domain and is involved in homophilic adhesion (1). In the cytoplasmic domain, there is a docking site for the multifunctional adaptor protein MAGI-1 (3). The extracellular region of human ESAM shows 90%, 74%, 69% and 67% aa identity with monkey, canine, mouse and rat extracellular ESAM, respectively. ESAM is expressed on endothelial cells, activated platelets and megakaryocytes, and can be found associated with cell-to-cell junctions. Whether ESAM is restricted to a particular junctional type is not clear (1, 2). ESAM deficient mice have no defect in vascularization but do have reduced angiogenic potential. This may be due to a decreased migratory response to FGF-2 (4).

    • References:
      1. Hirata, K-I, et al. (2001) J. Biol. Chem. 276:16223.
      2. Nasdala, I. et al. (2002) J. Biol. Chem. 277:16294.
      3. Wegmann, F. et al. (2004) Exp. Cell Res. 300:121.
      4. Ishida, T. et. al. (2003) J. Biol. Chem. 278:34598.
    • Long Name:
      Endothelial Cell Adhesion Molecule
    • Entrez Gene IDs:
      90952 (Human); 69524 (Mouse)
    • Alternate Names:
      2310008D05Rik; endothelial cell adhesion molecule; endothelial cell-selective adhesion molecule; ESAM; HUEL (C4orf1)-interacting protein; LP4791 protein; W117m
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