Recombinant Rat Growth Hormone R (GHR) Fc Chimera, CF 50 UG

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Recombinant Rat Growth Hormone R (GHR) Fc Chimera, CF 50 UG信息二维码

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产品介绍

    基本参数

    详细说明

    • Purity

      >90%, by SDS-PAGE under reducing conditions and visualized by silver stain

    • Endotoxin Level

      <0.10 EU per 1 μg of the protein by the LAL method.  

    • Activity

      Measured by its ability to inhibit GH-induced proliferation of Nb2‑11 rat lymphoma cells. Gout, P.W.     et al. (1980) Cancer Res.     40:2433. The ED    50 for this effect is 0.7-2.5 ng/mL in the presence of 0.2 ng/mL of rhGH.

    • Source

      Mouse myeloma cell line, NS0-derived

      Rat GHR
      (Phe19 - Arg265)
      Accession # P16310
      RIEGRMDHuman IgG1
      (Pro100 - Lys330)
      N-terminus
      C-terminus
    • Accession #

    • N-terminal Sequence    
      Analysis

      Phe19

    • Structure / Form

      Disulfide-linked homodimer

    • Predicted Molecular Mass

      55.1 kDa (monomer)

    • SDS-PAGE

      65-80 kDa, reducing conditions

    1211-GR

     

    Formulation Lyophilized from a 0.2 μm filtered solution in PBS.


    Reconstitution Reconstitute at 100 μg/mL in sterile PBS.



    Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.


    Stability & Storage:       Use a manual defrost freezer and avoid repeated freeze-thaw cycles.      

    • 12 months from date of receipt, -20 to -70 °C as supplied.

    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.

    • 3 months, -20 to -70 °C under sterile conditions after reconstitution.


    Background: Growth Hormone R/GHR

    Growth hormone (GH), also known as somatotropin, is a member of a family of growth factors that includes prolactin, placental lactogens, proliferins and somatolactin (1, 2). It is synthesized primarily by somatotropes in the anterior pituitary and is released as an endocrine hormone. Other cells and tissues, including lymphoid tissues, can also produce GH (3). GH is a pleiotropic molecule which can act directly or indirectly via IGF-I, to regulate growth and metabolism as well as enhance T cell survival and thymic functions (1, 2, 4). GH exerts its biological actions by binding to the GH receptor (GHR) that is present in many cell types (1, 2). Rat GHR cDNA encodes a 638 amino acid (aa) residue type I transmembrane protein with a 18 aa signal peptide, a 247 aa extracellular domain, a 24 aa transmembrane domain and a 349 aa cytoplasmic domain. An alternatively spliced 297 aa isoform of rat GHR also exists. This 279 aa variant corresponds to the serum GH-binding protein and is identical in sequence to the extracellular domain of the transmembrane protein up to Glu262 (5). Ligation of GHR by GH has been shown to result in receptor dimerization and activation of the JAK/STAT signaling cascade (6). The soluble GHBP has been shown to interfere with GH signaling by competing with the transmembrane receptor of GH. Alternatively, the GHBP has also been shown to enhance GH action by slowing GH clearance (5, 7).

    • References:

      1. Goffin, V. et al. (1996) Endocrine Rev. 17:385.

      2. Le Roith, D. et al. (2001) Endocrine Rev. 22:53.

      3. Clark, R. (1997) Endocr. Rev. 18:157.

      4. Welniak, L.A. et al. (2002) J. Leukoc. Biol. 71:381.

      5. Postel-Vinay, M.C. and J. Finidori (1995) Eur. J. Endocrinol. 133:654.

      6. Carter-Su, C. et al. (1996) Annu. Rev. Physiol. 58:187.

      7. Frick, G.P. et al. (1998) Endocrinology 139:2824.

    • Long Name:

      Growth Hormone Receptor

    • Entrez Gene IDs:

      2690 (Human); 14600 (Mouse); 25235 (Rat)

    • Alternate Names:

      GH receptor; GHBP; GHR; growth hormone binding protein; Growth Hormone R; growth hormone receptor; serum binding protein; Somatotropin receptor










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