Recombinant Human ULBP-2 Fc Chimera Protein, CF 50 UG

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Recombinant Human ULBP-2 Fc Chimera Protein, CF 50 UG信息二维码

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产品介绍

    基本参数

    详细说明

    • Purity
      >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
    • Endotoxin Level
      <0.10 EU per 1 μg of the protein by the LAL method.
    • Activity
      Measured by its ability to bind Recombinant Human NKG2D/CD314 Fc Chimera (Catalog # ) in a functional ELISA.
    • Source
      Mouse myeloma cell line, NS0-derived
      Human ULBP-2
      (Gly26-Ser217)
      Accession # Q9BZM5
      IEGRMD Human IgG1
      (Pro100-Lys330)
      N-terminus C-terminus
    • Accession #
    • N-terminal Sequence
      Analysis
      Gly26
    • Structure / Form
      Disulfide-linked homodimer
    • Predicted Molecular Mass
      48 kDa (monomer)
    • SDS-PAGE
      60-65 kDa, reducing conditions
    1298-UL
     
    Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
    Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
    Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
    Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
    • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
    Background: ULBP-2

    ULBP-2 is a member of a family of cell-surface proteins that function as ligands for human NKG2D. ULBP-2 has also been described under the names RaeT1H (retinoic acid early transcript), NKG2DL2, and ALCAN-alpha. The name ULBP-2 derives from the original identification of three proteins, ULBP-1, -2, and -3, as ligands for the human cytomegalovirus glycoprotein UL16; they were designated UL16 binding proteins (ULBP). The gene for ULBP-2 resides in a cluster of ten related genes, six of which encode potentially functional glycoproteins. Amino acid sequence identity within this family ranges from 30 – 60%. These proteins are distantly related to MHC class I proteins, but they possess only the alpha 1 and alpha 2 Ig-like domains, and they have no capacity to bind peptide or interact with beta 2-microglobulin. Some family members, including ULBP-2, are anchored to the membrane via a GPI-linkage, whereas others have transmembrane domains. ULBP-2 and several other family members are known to bind to human NKG2D, an activating receptor expressed on NK cells, NKT cells, gamma δ T cells, and CD8+ alpha beta T cells. Engagement of NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. The ULBPs are expressed on some tumor cells and have been implicated in tumor surveillance.

    • References:
      1. Cosman, D. et al. (2001) Immunity 14:123.
      2. Kubin, M. et al. (2001) Eur. J. Immunol. 31:1428.
      3. Sutherland, C. et al. (2002) J. Immunol. 168:671.
      4. Steinle, A. et al. (2001) Immunogenetics 53:279.
      5. Sutherland, C. et al. (2001) Immunol. Rev. 181:185.
      6. Pende, D. et al. (2002) Cancer Res. 62:6178.
      7. Radosavljevic, M. et al. (2002) Genomics 79:114.
      8. NKG2D and its Ligands (2002) www.rndsystems.com.
    • Long Name:
      UL16 Binding Protein-2
    • Entrez Gene IDs:
      80328 (Human)
    • Alternate Names:
      ALCAN-alpha; N2DL2; N2DL-2; NKG2D ligand 2; NKG2DL2; RAET1H; RAET1HNKG2DL2; retinoic acid early transcript 1 H; Retinoic acid early transcript 1H; UL16 binding protein 2; UL16-binding protein 2; ULBP2; ULBP-2
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