• Accession #

• N-terminal Sequence    
  Analysis

  Thr41 & Glu43

• Structure / Form

  Disulfide-linked homodimer

• Predicted Molecular Mass

  40 kDa

• SDS-PAGE

  51-57 kDa, reducing conditions

Data Images

Background: PVRIG

Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34 kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family (1). It is composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain. The intracellular domain contains two tyrosine residues, one within an ITIM-like motif that is a potential docking site for phosphatases (1). The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. The human PVRIG gene is preferentially expressed in lymphocytes, such as T cells and NK cells, but not in monocyte derived dendritic cells (1). PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells (1).

• References:

1. Zhu, Y., et.al. (2016) J. Exp. Med. 213:167.

• Long Name:

  Poliovirus Receptor Related Immunoglobulin Domain Containing

• Entrez Gene IDs:

  79037 (Human); 620147 (Mouse)

• Alternate Names:

  C7orf15; C7orf15MGC138295; CD112R; MGC104322; MGC138297; MGC2463; poliovirus receptor related immunoglobulin domain containing; Poliovirus receptor-related immunoglobulin domain-containing protein; PVRIG; transmembrane protein PVRIG