Recombinant Human Siglec-15 Fc Chimera Protein, CF EA

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Recombinant Human Siglec-15 Fc Chimera Protein, CF EA信息二维码

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    基本参数

    详细说明

    • Purity
      >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
    • Endotoxin Level
      <0.10 EU per 1 μg of the protein by the LAL method.
    • Activity
      Measured by its binding ability in a functional ELISA. When Neu5Ac(a2-6)GalNAc-PAA-biotin is immobilized onto a Streptavidin-coated plate, Recombinant Human Siglec-15 Fc Chimera binds with an ED 50 of 150-900 ng/mL.
    • Source
      Chinese Hamster Ovary cell line, CHO-derived
      Human Siglec-15
      (Phe20-Thr263)
      Accession # Q6ZMC9
      IEGRMD Human IgG1
      (Pro100-Lys330)
      N-terminus C-terminus
    • Accession #
    • N-terminal Sequence
      Analysis
      Phe20
    • Structure / Form
      Disulfide-linked homodimer
    • Predicted Molecular Mass
      53 kDa
    • SDS-PAGE
      53-64 kDa, reducing conditions
    9227-SL
     
    Formulation Lyophilized from a 0.2 μm filtered solution in PBS, NaCl, CHAPS and Trehalose.
    Reconstitution Reconstitute at 200 μg/mL in water.
    Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
    Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
    • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
    Data Images
    Bioactivity

    When Neu5Ac(a2-6)GalNAc-PAA-biotin is immobilized onto aStreptavidin-coated plate, Recombinant Human Siglec-15 Fc Chimera (Catalog # 9227-SL) bindswith an ED50 of
    150-900 ng/mL.
    Background: Siglec-15
    Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules (1). Mature human Siglec-15 consists of a 244 amino acid (aa) extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain (2). Within the ECD, human Siglec-15 shares 85% aa sequence identity with mouse and rat Siglec-15. Alternative splicing generates an additional isoform that lacks the signal peptide and first Ig-like domain. Siglec-15 associates with the signaling molecules DAP12 and DAP10 (2-5). It is expressed on osteoclasts, macrophages, and dendritic cells (2-6) and binds to the sialyl-Tn antigen (2, 3, 6). This interaction induces the production of TGF-beta by tumor-associated macrophages (3). Siglec-15 function is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts (4-6).
    • References:
      1. Humphrey, M.B. and M.C. Nakamura (2015) Clin. Rev. Allergy Immunol. PMID 26573914.
      2. Angata, T. et al. (2007) Glycobiology 17:838.
      3. Takamiya, R. et al. (2013) Glycobiology 23:178.
      4. Kameda, Y. et al. (2013) J. Bone Miner. Res. 28:2463.
      5. Stuible, M. et al. (2014) J. Biol. Chem. 289:6498.
      6. Ishida-Kitagawa, N. et al. (2012) J. Biol. Chem. 287:17493.
    • Long Name:
      Sialic Acid Binding Ig-like Lectin 15
    • Entrez Gene IDs:
      284266 (Human); 620235 (Mouse); 498888 (Rat)
    • Alternate Names:
      CD33 antigen-like 3SIGLEC-15; CD33 molecule-like 3; CD33L3; HsT1361; sialic acid binding Ig-like lectin 15; sialic acid-binding Ig-like lectin 15; Siglec15; Siglec-15
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