Recombinant Human Stanniocalcin 2/STC-2 Protein, CF 50 UG

所属行业:行业前沿     有0人感兴趣

Recombinant Human Stanniocalcin 2/STC-2 Protein, CF 50 UG信息二维码

微信扫码

 
基础投资电议
推荐指数
  • 区域全国
  • 留言暂无
  • 浏览0
  • 更新2024-11-24 19:53
  • 到期长期有效






更多>我还有产品
Recombinant Human DC-SIGN/CD209 Fc Chimera Protein, CF  50 UG Recombinant Human CEACAM-19 Fc Chimera Protein, CF  50 UG Recombinant Human Stanniocalcin 1/STC-1 Protein, CF  50 UG CellXVivo Human Monocyte-derived DC Differentiation Kit  1 KT CellXVivo Mouse Treg Cell Differentiation Kit  1 KT

产品介绍

    基本参数

    详细说明

    • Purity

      >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.

    • Endotoxin Level

      <0.10 EU per 1 μg of the protein by the LAL method.  

    • Activity

      Measured by its ability to inhibit Wnt-3a-induced alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells. The ED    50 for this effect is 60-360 ng/mL in the presence of 10 ng/mL of Recombinant Mouse Wnt‑3a (Catalog # ).

    • Source

      Mouse myeloma cell line, NS0-derived Thr25-Arg302, with a C-terminal 6-His tag

    • Accession #

    • N-terminal Sequence    
      Analysis

      Thr25

    • Structure / Form

      Disulfide-linked homodimer

    • Predicted Molecular Mass

      31 kDa

    • SDS-PAGE

      34-43 kDa, reducing conditions

    9405-SO

     

    Formulation Lyophilized from a 0.2 μm filtered solution in PBS.


    Reconstitution Reconstitute at 500 μg/mL in PBS.



    Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.


    Stability & Storage:       Use a manual defrost freezer and avoid repeated freeze-thaw cycles.      

    • 12 months from date of receipt, -20 to -70 °C as supplied.

    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.

    • 3 months, -20 to -70 °C under sterile conditions after reconstitution.


    Data Images

    Bioactivity      


           

    Recombinant Human Stanniocalcin 2/STC-2 (Catalog # 9405-SO) inhibits Recombinant Mouse Wnt-3a induced alkaline phosphatase production by MC3T3-E1 mouse preosteoblast cells. The ED50 for this effect is 60-360 ng/ml in the presence of 10 ng/ml of Recombinant Mouse Wnt‑3a (Catalog # ).

    Background: Stanniocalcin 2/STC-2

    Stanniocalcin 2 (STC-2) is a secreted disulfide-linked homodimeric glycoprotein hormone that is related to the STC protein first discovered from corpuscles of stannius in fish (1). The STC-2 has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues (2). Its C-terminus contains a cluster of histidine residues which may interact with metal ions (1). STC-2 is expressed in a wide variety of tissues. In the ovary, STC-2 has been shown to be a paracrine hormone that regulates granulosa cell function (1). The amino acid sequence of human mature STC-2 is 36% identical to that of human STC-1. It is also 99% and 88% identical to that of monkey and mouse STC-2, respectively (3). STC-2 enhances mesenchymal stem cell survival (4), promotes cell proliferation in cervical cancer (5), suppresses breast cancer cell migration and invasion (6), promotes osteoblast differentiation (7), and inhibits longitudinal bone growth directly at the growth plate (8). It is also a biomarker for cervical and lung cancers (9, 10),

    • References:

      1. Luo, C. et al. (2005). Endocrinology 146:469.

      2. Tagliabracci, V. S. et al. (2015). Cell 161:1619.

      3. Ishibashi, K. et al. (1998). Biochem. Biophys. Res. Commun. 250:252.

      4. Kim PH, et al. (2015) BMB Rep. 48:702.

      5. Wang Y, et al. (2015) Biochem Biophys Res Commun. 466:362.

      6. Hou J, et al. (2015) PLoS One. 10:e0122179.

      7. Zhou J, et al. (2016) Mol Med Rep. 14:5653.

      8. Wu S, et al. (2006) J Biol Chem. 281: 5120.

      9. Shen XJ, et al. (2014) Int J Clin Exp Pathol. 7: 8770.

      10. Na SS, et al. (2015) Biochim Biophys Acta. 1854:668.

    • Entrez Gene IDs:

      8614 (Human); 20856 (Mouse)

    • Alternate Names:

      Stanniocalcin 2; stanniocalcin-2; STC2; STC-2; STC-2Stanniocalcin-related protein; STC-related protein; STCRP


    举报收藏 0评论 0
 
热门项目排行榜快速发布信息
14-(2-碘代乙基)辛基苯 9
2高温波导测试
3格列美脲 98%+ RG  5g
4N,N-Diethyl-cyclohexan
54-溴-3,5-二氯三氟甲苯
6Recombinant Human LILR
行业前沿排行榜快速发布信息
14-(2-碘代乙基)辛基苯 9
2格列美脲 98%+ RG  5g
3N,N-Diethyl-cyclohexan
44-溴-3,5-二氯三氟甲苯
5N-Methyl-DL-leucine hy
64-溴-3,5-二氯三氟甲苯
最新加入项目快速发布信息
1TWS用胶
2电感胶
3电子胶
4环氧AB胶
5导电银胶(晶振)
6固晶胶

猜你喜欢产品快速发布信息

相关栏目

还没找到您需要的行业前沿产品?立即发布您的求购意向,让行业前沿公司主动与您联系!

立即发布项目意向

免责声明

本网页所展示的有关【Recombinant Human Stanniocalcin 2/STC-2 Protein, CF 50 UG_行业前沿_云试剂自营四店】的信息/图片/参数等由云试剂的会员【云试剂自营四店】提供,由云试剂会员【云试剂自营四店】自行对信息/图片/参数等的真实性、准确性和合法性负责,本平台(本网站)仅提供展示服务,请谨慎交易,因交易而产生的法律关系及法律纠纷由您自行协商解决,本平台(本网站)对此不承担任何责任。您在本网页可以浏览【Recombinant Human Stanniocalcin 2/STC-2 Protein, CF 50 UG_行业前沿_云试剂自营四店】有关的信息/图片/价格等及提供【Recombinant Human Stanniocalcin 2/STC-2 Protein, CF 50 UG_行业前沿_云试剂自营四店】的商家公司简介、联系方式等信息。

联系方式

在您的合法权益受到侵害时,欢迎您向邮箱发送邮件,或者进入《网站意见反馈》了解投诉处理流程,我们将竭诚为您服务,感谢您对云试剂的关注与支持!

按排行字母分类找加盟项目:

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z