Complement C1q tumor necrosis factor-related protein 2 (C1qTNF2), also known as CTRP-2 or zacrp2 is an approximately 30 kDa member of the C1q family of secreted proteins (1, 2). Like other members of that family, CTRP2 contains a collagen-like region and one C1q-like domain (3). CTRP2 shares 42% amino acids identity with adiponectin at the presumed functional globular domain (4) and is expressed in stromal vascular cells (5). CTRP2 circulates as a trimeric glycoprotein in plasma (6), and can also form homo-oligomer or hetero-oligomer with other CTRPs (7). C1qTNF2 has been shown to phosphorylate AMPK and ACC in skeletal muscle leading to an increase in glycogen accumulation and fatty acid oxidation (8). C1qTNFs are of clinical interest as diagnostic or therapeutic targets in diseases where energy homeostasis is unbalanced such as obesity, insulin resistance, and type 2 diabetes (2).