Recombinant Mouse GFR alpha-2 Fc Chimera Protein, CF 100 UG

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Recombinant Mouse GFR alpha-2 Fc Chimera Protein, CF 100 UG信息二维码

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产品介绍

    基本参数

    详细说明

    • Purity
      >95%, by SDS-PAGE under reducing conditions and visualized by silver stain
    • Endotoxin Level
      <1.0 EU per 1 μg of the protein by the LAL method.
    • Activity
      Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse Neurturin (Catalog # ) at 1 μg/mL binds Recombinant Mouse GFR alpha ‑2/GDNF R alpha ‑2 Fc Chimera with an apparent K D <5 nM.
    • Source
      Mouse myeloma cell line, NS0-derived
      Mouse GFRa-2
      (Ser22-Ser441)
      Accession # Q3UUD8
      DIEGRMD Human IgG1
      (Pro100-Lys330)
      6-His tag
      N-terminus C-terminus
    • Accession #
    • N-terminal Sequence
      Analysis
      Ser22
    • Predicted Molecular Mass
      74 kDa (monomer)
    • SDS-PAGE
      90 kDa, reducing conditions
    429-FR
     
    Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
    Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
    Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
    Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
    • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
    Background: GFR alpha-2/GDNF R alpha-2

    Glial cell line-derived growth factor (GDNF), neurturin (NTN), persephin (PSP) and artemin, distant members of the TGF-beta  superfamily, are neurotrophic factors for a variety of neuronal populations in the central and peripheral nervous systems. The bioactivities of GDNF and NTN are mediated through a receptor complex composed of the non ligand-binding signaling subunit (c-Ret receptor tyrosine kinase) and either of two ligand binding subunits, GDNF receptor alpha -1 (GFR alpha -1, also known as Trn R1) or GFR alpha -2 (also known as Trn R2). GFR alpha -1 and -2 are members of a family of at least four cysteine-rich glycosyl-phosphatidylinositol (GPI)-linked cell surface proteins that share conserved placements of many of their cysteine residues. Binding of GDNF or NTN to membrane-associated GFR alpha -1 or GFR alpha -2 initiates the association with and activation of the Ret tyrosine kinase.

    Mouse GFR alpha -2 cDNA encodes a 463 amino acid (aa) residue protein with a putative N-terminal 21 aa residue hydrophobic signal peptide. Like other GPI-linked proteins, rat GFR alpha -2 has a C-terminal hydrophobic region which is preceded by a 3 aa residue (SGS) GPI-binding site. Human GFR alpha -2 shares 96.5% amino acid identity with mouse GFR alpha -2. The expression of the various GFR alpha s are differentially regulated in the central and peripheral nervous system, suggesting complementary roles for the GFR alpha s in mediating the activities of the GDNF family of neurotrophic factors.

    • References:
      1. Thompson, J. et al. (1998) Mol. Cell Neurosci. 11:117.
      2. Trupp, M. et al. (1998) Mol. Cell Neurosci. 11:47.
      3. Baloh, R.H. et al. (1998) Proc. Natl. Acad. Sci. USA 95:5801.
      4. Baloh, R.H. et al. (1998) Neuron 21:1291.
    • Long Name:
      Glial Cell line-derived Neurotrophic Factor Receptor alpha 2
    • Entrez Gene IDs:
      2675 (Human); 14586 (Mouse)
    • Alternate Names:
      GDNF family receptor alpha 2; GDNF family receptor alpha-2; GDNF R alpha-2; GDNF receptor alpha-2; GDNF receptor beta; GDNFR-alpha-2; GDNFR-beta; GDNFRBRET ligand 2; GFR alpha2; GFR alpha-2; GFRA2; GFRa-2; GFR-alpha 2; GFR-alpha-2; glial cell line derived neurotrophic factor receptor, beta; Neurturin receptor alpha; NRTNR-alpha; NTNRA; NTNR-alpha; PI-linked cell-surface accessory protein; RETL2TGF-beta-related neurotrophic factor receptor 2; TGF-beta related neurotrophic factor receptor 2; TRN receptor, GPI-anchored; TRNR2NRTNR-ALPHA
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