Recombinant Mouse IL-3 R beta Fc Chimera Protein, CF 100 UG

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Recombinant Mouse IL-3 R beta Fc Chimera Protein, CF 100 UG信息二维码

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3-Amino-5-methoxycarbonylphenylboronic acid, pinacol ester  1 g 2,3-Dichloro-6-(trifluoromethyl)benzyl bromide  1 g 1-(4-Fluorophenyl)-5-methoxycarbonyl-2(1H)-pyridinone  1 g N,N-Diethyl-cyclohexane-1,4-diamine  1 g N-Methyl-DL-leucine hydrochloride  5 g N-(2-Chloroethyl) 3-boronobenzamide  5 g

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    基本参数

    详细说明

    • Purity
      >90%, by SDS-PAGE under reducing conditions and visualized by silver stain
    • Endotoxin Level
      <0.10 EU per 1 μg of the protein by the LAL method.
    • Activity
      Measured by its ability to inhibit the IL-3-induced proliferation of NFS‑60 mouse myelogenous leukemia lymphoblast cells. The ED 50 for this effect is 0.2‑1 µg/mL in the presence of 2.5 µg/mL soluble rmIL-3 R alpha /Fc Chimera and 0.5 ng/mL of rmIL-3..
    • Source
      Mouse myeloma cell line, NS0-derived
      Mouse IL-3 R beta
      (His23 - Trp440)
      Accession # Q3U3P4
      IEGRID Human IgG1
      (Pro100 - Lys330)
      N-terminus C-terminus
    • Accession #
    • N-terminal Sequence
      Analysis
      His23
    • Structure / Form
      Disulfide-linked homodimer
    • Predicted Molecular Mass
      74.9 kDa (monomer)
    • SDS-PAGE
      80 kDa, reducing conditions
    549-R3
     
    Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
    Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
    Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
    Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
    • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
    Background: IL-3 R beta

    Interleukin 3 (IL-3) is a pleiotropic cytokine produced primarily by activated T cells or mast cells. IL-3 stimulates the proliferation and differentiation of hemopoietic cells including the pluripotent hematopoietic stem cells as well as various lineage-committed cells. The biological effects of IL-3 on the various cell types are mediated by the binding of IL-3 to specific cell surface receptor complexes. The functional high-affinity IL-3 receptor is a heterodimer consisting of a ligand binding alpha subunit and the beta subunit. The alpha subunit alone binds IL-3 with low affinity. The beta subunit is required for the high-affinity binding of IL-3 to the heterodimeric receptor complex. The beta subunit has also been found to be a component of the high-affinity receptor complex for IL-5 and GM-CSF and is also referred to as the beta common ( beta c) chain. In the mouse, there are two IL-3 R beta proteins. The first identified mouse IL-3 R beta was also called AIC2A and binds IL-3 with low affinity (1). The second mIL-3 R beta was referred to as AIC2B (2). AIC2B doesn’t bind IL-3 and is the homolog of the human IL-3 R beta. AIC2A was found to be the result of a gene duplication event. Both the alpha and the beta  subunits are members of the cytokine receptor superfamily (3).

    • References:
      1. Itoh, N. et al. (1990) Science 247:324.
      2. Gorman, D.M. et al. (1990) Proc. Natl. Acad. Sci. USA 87:5459.
      3. Schrader, J.W. in Cytokine Reference, (2001) J.J. Oppenheim and M. Feldmann, eds. Academic Press, New York, p. 1899.
    • Long Name:
      Interleukin 3 Receptor beta
    • Entrez Gene IDs:
      12984 (Mouse)
    • Alternate Names:
      AIC2A; BetaIl3; Bil3; Csfgmrb; IL-3 R beta; IL3R beta; IL3R; IL3RB; IL-3Rb; Il3rb2
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