Recombinant Mouse Endoglin/CD105 Fc Chimera Protein, CF 25 UG

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Recombinant Mouse Endoglin/CD105 Fc Chimera Protein, CF 25 UG信息二维码

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3-Amino-5-methoxycarbonylphenylboronic acid, pinacol ester  1 g 2,3-Dichloro-6-(trifluoromethyl)benzyl bromide  1 g 1-(4-Fluorophenyl)-5-methoxycarbonyl-2(1H)-pyridinone  1 g N,N-Diethyl-cyclohexane-1,4-diamine  1 g N-Methyl-DL-leucine hydrochloride  5 g N-(2-Chloroethyl) 3-boronobenzamide  5 g

产品介绍

    基本参数

    详细说明

    • Purity
      >90%, by SDS-PAGE under reducing conditions and visualized by silver stain
    • Endotoxin Level
      <0.01 EU per 1 μg of the protein by the LAL method.
    • Activity
      Measured by its ability to inhibit BMP-10-induced alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells. The ED 50  for this effect is 0.15-0.75 μg/mL.
    • Source
      Mouse myeloma cell line, NS0-derived
      Mouse Endoglin
      (Glu27-Gly581)
      Accession # Q8K100
      IEGRMD Human IgG1
      (Pro100-Lys330)
      N-terminus C-terminus
    • Accession #
    • N-terminal Sequence
      Analysis
      Glu27
    • Structure / Form
      Disulfide-linked homodimer
    • Predicted Molecular Mass
      86 kDa (monomer)
    • SDS-PAGE
      100-110 kDa, reducing conditions
    1320-EN
     
    Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
    Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
    Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
    Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
    • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
    Background: Endoglin/CD105

    Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins (1-3). Endoglin and betaglycan/T beta RIII are type III receptors for TGF beta superfamily ligands, sharing 71% amino acid (aa) identity within the transmembrane (TM) and cytoplasmic domains. Endoglin is highly expressed on proliferating vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta, with lower amounts on hematopoietic, mesenchymal and neural crest stem cells, activated monocytes, and lymphoid and myeloid leukemic cells (2-5). Mouse Endoglin cDNA encodes 653 aa including a 26 aa signal sequence, a 555 aa extracellular domain (ECD) with an orphan domain and a two-part ZP domain, a TM domain and a 47 aa cytoplasmic domain (1‑3). A mouse isoform with a 35 aa cytoplasmic domain (S-endoglin) can oppose effects of long (L) Endoglin (6, 7). The mouse Endoglin ECD shares 69%, 84%, 62%, 63% and 66% aa identity with human, rat, bovine, porcine and canine Endoglin, respectively. Endoglin homodimers interact with TGF-beta 1 and TGF-beta 3 (but not TGF-beta 2), but only after binding T beta RII (8). Similarly, they interact with activin-A and BMP-7 via activin type IIA or B receptors, and with BMP-2 via BMPR-1A/ALK-3 or BMPR-1B/ALK-6 (9). BMP-9, however, is reported to bind Endoglin directly (10). Endoglin modifies ligand-induced signaling in multiple ways. For example, expression of Endoglin can inhibit TGF-beta 1 signals but enhance BMP7 signals in the same myoblast cell line (11). In endothelial cells, Endoglin inhibits T beta RI/ALK5, but enhances ALK1-mediated activation (12). Deletion of mouse Endoglin causes lethal vascular and cardiovascular defects, and human Endoglin haploinsufficiency can a cause the vascular disorder, hereditary hemorrhagic telangiectasia type I (13, 14). These abnormalities confirm the essential function of Endoglin in differentiation of smooth muscle, angiogenesis, and neovascularization (2-4, 12-14). In preeclampsia of pregnancy, high levels of proteolytically generated soluble Endoglin and VEGF R1 (sFLT1), along with low placental growth factor (PlGF), are pathogenic due to antiangiogenic activity (15).

    • References:
      1. Ge, A.Z. and Butcher, E.C. (1994) Gene 138:201.
      2. ten Dijke, P. et al. (2008) Angiogenesis 11:79.
      3. Bernabeu, C. et al. (2007) J. Cell. Biochem. 102:1375.
      4. Mancini, M.L. et al. (2007) Dev. Biol. 308:520.
      5. Moody, J.L. et al. (2007) Stem Cells 25:2809.
      6. Velasco, S. et al. (2008) J. Cell Sci. 121:913.
      7. Perez-Gomez, E. et al. (2005) Oncogene 24:4450.
      8. Cheifetz, S, et al. (1992) J. Biol. Chem. 267:19027.
      9. Barbara, N.P. et al. (1999) J. Biol. Chem. 274:584.
      10. Scharpfenecker, M. et al. (2007) J. Cell Sci. 120:964.
      11. Scherner, O. et al. (2007) J. Biol. Chem. 282:13934.
      12. Pece-Barbara, N. et al. (2005) J. Biol. Chem. 280:27800.
      13. Arthur, H.M. et al. (2000) Dev. Biol. 217:42.
      14. Lebrin, F. and C.L. Mummery (2008) Trends Cardiovasc. Med. 18:25.    
      15. Venkatesha, S. et al. (2006) Nat. Med. 12:642.
    • Entrez Gene IDs:
      2022 (Human); 13805 (Mouse); 497010 (Rat)
    • Alternate Names:
      CD105 antigen; CD105; Endoglin; ENDOsler-Rendu-Weber syndrome 1; ENG; HHT1FLJ41744; ORW; ORW1
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