Recombinant Human LILRB1/CD85j/ILT2 Protein, CF 50 UG

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Recombinant Human LILRB1/CD85j/ILT2 Protein, CF 50 UG信息二维码

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  • 更新2024-07-25 20:43
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3-Amino-5-methoxycarbonylphenylboronic acid, pinacol ester  1 g 2,3-Dichloro-6-(trifluoromethyl)benzyl bromide  1 g 1-(4-Fluorophenyl)-5-methoxycarbonyl-2(1H)-pyridinone  1 g N,N-Diethyl-cyclohexane-1,4-diamine  1 g N-Methyl-DL-leucine hydrochloride  5 g N-(2-Chloroethyl) 3-boronobenzamide  5 g

产品介绍

    基本参数

    详细说明

    • Purity
      >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
    • Endotoxin Level
      <0.10 EU per 1 μg of the protein by the LAL method.
    • Activity
      Measured by its binding ability in a functional ELISA. When Recombinant Human LILRB1/CD85j/ILT2 is coated at 2 µg/mL, Recombinant Human Angiopoietin-like Protein 7/ANGPTL7 (Catalog # ) binds with a typical ED 50 of 75-450 ng/mL.
    • Source
      Human embryonic kidney cell, HEK293-derived
      Human LILRB1
      (Gly24-His458)
      Accession # Q8NHL6
      HHHHHH
      N-terminus C-terminus
    • Accession #
    • N-terminal Sequence
      Analysis
      Gly24
    • Structure / Form
      Monomer
    • Predicted Molecular Mass
      48 kDa
    • SDS-PAGE
      65-82 kDa, reducing conditions
    8989-T2
     
    Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
    Reconstitution Reconstitute at 100 μg/mL in PBS.
    Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
    Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
    • 12 months from date of receipt, -20 to -70 °C as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
    • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
    Background: LILRB1/CD85j/ILT2
    LILRB1, also known as CD85j and ILT2, is a 110 kDa transmembrane glycoprotein in the LILR immunoregulatory protein family (1). Mature human LILRB1 consists of a 438 amino acid (aa) extracellular domain (ECD) with 4 tandem Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 4 inhibitory ITIM motifs (2). Alternative splicing generates an additional isoform that lacks the transmembrane and cytoplasmic regions (3). LILRB1 is expressed on the surface of B cells and monocytes, as well as subsets of NK cells, memory/effector CD8 + T cells, gamma δ T cells, and monocyte-derived dendritic cells (3-7). LILRB1 binds to MHC-I as well as non-classical MHC-I molecules ( e.g. HLA-F, HLA-G, and HLA-B27) and the MHC-I mimetic UL18 encoded by cytomegalovirus (3, 5, 8-10). R&D Systems
    in-house testing indicates that LILRB1 also binds to Angiopoietin-like 7. Ligation of LILRB1 inhibits the antigen induced proliferation and activation of CD8 + T cells, CD4 + T cells, NK cells, and gamma δ T cells (3, 4, 11-13). On dendritic cells, ligation inhibits the production of IL-10, IL-12p70, and TGF-beta and protects from Fas-mediated apoptosis (7).
    • References:
      1. Thomas, R. et al. (2010) Clin. Rev. Allergy Immunol. 38:159.
      2. Samaridis, J. and M. Colonna (1997) Eur. J. Immunol. 27:660.
      3. Colonna, M. et al. (1997) J. Exp. Med. 186:1809.
      4. Harly, C. et al. (2011) Blood 117:2864.
      5. Cosman, D. et al. (1997) Immunity 7:273.
      6. Young, N.T. et al. (2001) J. Immunol. 166:3933.
      7. Young, N.T. et al. (2008) Blood 111:3090.
      8. Lepin, E.J.M. et al. (2000) Eur. J. Immunol. 30:3552.
      9. Shiroishi, M. et al. (2003) Proc. Natl. Acad. Sci. USA 100:8856.
      10. Allen, R.L. et al. (2001) J. Immunol. 167:5543.
      11. Ince, M.N. et al. (2004) Immunology 112:531.
      12. Saverino, D. et al. (2000) J. Immunol. 165:3742.
      13. Saverino, D. et al. (2002) J. Immunol. 168:207.
    • Long Name:
      Leukocyte Immunoglobulin-like Receptor, Subfamily A (with TM domain), Member 1
    • Entrez Gene IDs:
      10859 (Human)
    • Alternate Names:
      CD85 antigen-like family member J; CD85j antigen; CD85j; Ig-like transcript 2; ILT2; ILT-2; ILT2FLJ37515; Immunoglobulin-like transcript 2; leukocyte Ig-like receptor-1; Leukocyte immunoglobulin-like receptor 1; leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform; leukocyte immunoglobulin-like receptor subfamily B member 1; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains); LILRB1; LIR1; LIR1LIR-1MIR-7CD85MIR7CD85 antigen; member 1; MIR7; Monocyte/macrophage immunoglobulin-like receptor 7
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