Docosahexaenoic acid (DHA) is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development. Maresin 1 (7(R)-MaR1) is a 7,14-DHA formed from 14S-hydroperoxy DHA supplied exogenously to resident peritoneal murine macrophages activated with zymosan A. It potently reduces infiltration of neutrophils into the murine peritoneum in zymosan A-induced peritonitis when given intravenously (0.2 ng) and significantly increases phagocytosis of FITC-labeled zymosan A by isolated mouse macrophages (0.1-100 nM). 7(S)-MaR1 is an epimer of the active 7(R)-MaR1.

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