详细说明
同义词： (RS)-Alpha-cyclopropyl-4-phosphonophenylglycine
应用； The most potent group II/III mGluR antagonist
CAS号码: 183364-82-1
纯度: ≥98%
分子量: 271.21
分子式: C11H14NO5P
* 参考分析证明 大量特定数据 (包括水 含量). (RS)-CPPG is the most potent group II/III mGluR antagonist, with approx. 20-fold selectivity for group III over group II. (RS)-CPPG is an inhibitor of mGluR-2, mGluR-3, mGluR-4, mGluR-6, mGluR-7 and mGLuR-8.
参考文献
1. Toms, N.J., et al. 1996. Br. J. Pharmacol. 119: 851-854. PMID: 8922731
2. Jane, D.E., et al. 1996. Neuropharmacology 35: 1029-1035. PMID: 9121605
3. Schoepp, D.D., et al. 1999. Neuropharmacology. 38: 1431-1476. PMID: 10530808
外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in water (>5 mg/ml), dilute aqueous base, and NaOH (100 mM, 27mg/100mM NaOH = 100mM stock at pH7).
保存 :
Store at 4° C
熔点 :
304.03° C (Predicted)
沸点 :
541.54° C at 760 mmHg (Predicted)
密度 :
1.57 g/cm 3 (Predicted)
折射率 :
n 20 D 1.65 (Predicted)
IC50 :
mGlu group III : IC 50 = 2.2 nM; mGlu group II: IC 50 = 46.2 nM
pK值 :
pK a: 1.55 (Predicted), pK b: 10.39 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
PubChem CID :
2878
MDL 号码 :
MFCD00673967
SMILES :
C1CC1C(C2=CC=C(C=C2)P(=O)(O)O)(C(=O)O)N
4006226992