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基本信息
- 抑制剂DX600
- DX600
- Ac-Gly-DL-Asp-DL-Tyr-DL-Ser-DL-His-DL-Cys(1)-DL-Ser-DL-Pro-DL-Leu-DL-Arg-DL-Tyr-DL-Tyr-DL-Pro-DL-Trp-DL-Trp-DL-Lys-DL-Cys(1)-DL-xiThr-DL-Tyr-DL-Pro-DL-Asp-DL-Pro-DL-Glu-Gly-Gly-Gly-NH2.TFA
- White to Off-White Solid
- -80°C, 2 years; -20°C, 1 year (Sealed storage, away from moisure and light).
生物活性
DX600 is a selective ACE2 specific inhibitor (KD: 1.3 nM), and does not cross-react with ACE. DX600 exacerbates diabetes-induced cardiovascular dysfunction and the increase in cardiac and renal NOX activity[1][2][3].
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