28822-58-4
3-异丁基-1-甲基黄嘌呤(3,7-dihydro-3-isobutyl-1-methyl-1H-purine-2,6-dione)
CAS: 28822-58-4
化学式: C10H14N4O2
| 中文名 | 3-异丁基-1-甲基黄嘌呤 |
| 英文名 | 3,7-dihydro-3-isobutyl-1-methyl-1H-purine-2,6-dione |
| 别名 | 3-异丁基-1-甲基黄嘌呤 3-异丁基-1-甲基黄嘌呤(IBMX) 3-异丁基-1-甲基-2,6(1H,3H)-嘌呤二酮 3-异丁基-1-甲基-1H-嘌呤-2,6(3H,9H)-二酮 3-异丁基-1-甲基-3,9-二氢-1H-嘌呤-2,6-二酮 3-ISOBUTYL-1-METHYLXANTHINE 3-异丁基-1-甲基黄嘌呤 IBMX |
| 英文别名 | IMX Isobutylmethylxanthine Methylisobutylxanthine 3-isobutyl-1-methyl-xanthin 3-Isobutyl-1-methylanxthine 3,7-dihydro-3-isobutyl-1-methyl-1H-purine-2,6-dione 3-Isobutyl-1-methyl-3,7-dihydro-1H-purine-2,6-dione 3,7-dihydro-1-methyl-3-(2-methylpropyl)-1h-purine-6-dione 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)- |
| CAS | 28822-58-4 |
| EINECS | 249-259-3 |
| 化学式 | C10H14N4O2 |
| 分子量 | 222.24 |
| InChI | InChI=1/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) |
| InChIKey | APIXJSLKIYYUKG-UHFFFAOYSA-N |
| 密度 | 1.2042 (rough estimate) |
| 熔点 | 200-201°C(lit.) |
| 沸点 | 363.42°C (rough estimate) |
| 闪点 | 223.3°C |
| 蒸汽压 | 3.89E-08mmHg at 25°C |
| 溶解度 | DMSO: 1m，温和升温 |
| 折射率 | 1.6500 (estimate) |
| 酸度系数 | 8.61±0.70(Predicted) |
| 存储条件 | -20°C |
| 稳定性 | 从提供的购买之日起稳定2年。DMSO或乙醇中的溶液可以在-20 °C下储存长达3个月。 |
| 外观 | 粉末 |
| 颜色 | off-white |
| BRN | 247859 |
| MDL号 | MFCD00005584 |
| 体外研究 | At 100 μM, KMUP-1 (a xanthine derivative) and IBMX are the most effective at inducing tracheal relaxation; the magnitude of the relaxation responses induced by KMUP-1 and IBMX are not significantly different. IBMX (100 μM) activates renal outer medullary K + (ROMK) channels (n=6, P<0.05) and prevents further channel activation by ANG II (n=6, P=NS) or cGMP. Of note is that pretreatment of cortical collecting duct (CCDs) isolated from high-K + (HK)-fed rats with IBMX (100 μM) for 20 min leads to a significant increase in tubular cAMP content to 1.43±0.35 pg/mm tubule length (n=14) compare with that measured in vehicle-treated controls (0.61±0.13 pg/mm tubule length, n=12, P<0.05). |
| 体内研究 | IBMX, a non-selective PDE inhibitor significantly decreases the liver glycogen storage (mg/g, IBMX 22±1.5 P<0.001). In comparison with the control group, IBMX and mc5 significantly increase plasma glucose (blood glucose, mg/dl, control=141±3, IBMX=210±17 P<0.001 and mc5=191±13 P<0.01) while other test compounds (mc1, mc6, MCPIP and Win 47203) do not produce significant effect (control=141±3, mc1 160±7, mc6 175±9, MCPIP 179±8 and Win 47203 116±2 P>0.05) also mc2 does not change plasma glucose (control=141±3 and mc2=145±5). IBMX has the highest efficacy on increasing plasma glucose. Treatments with IBMX and Apocynin significantly decrease cold-induced elevation of right ventricular (RV) systolic pressure (23.5±1.8 and 24.2±0.6 mmHg, respectively) although they do not decrease RV pressure to the warm control levels. IBMX or Apocynin significantly reduces medial layer thickness (19.0±0.9, and 16.9±0.8 μm, respectively) and increases lumen diameter (62.7±4.2, and 59.5±4.3 μm, respectively) of small PAs in cold-exposed rats. |
| 危险品标志 | Xn - 有害物品 |
| 风险术语 | 22 - 吞食有害。 |
| 安全术语 | 24/25 - 避免与皮肤和眼睛接触。 |
| WGK Germany | 3 |
| RTECS | ZD8500000 |
| 海关编号 | 29335990 |
28822-58-4 - 简介
3-异丁基-1-甲基黄嘌呤，也被称为异戊基咖啡因，是一种化学物质。下面是关于它的性质，用途，制法和安全信息的介绍：性质：
3-异丁基-1-甲基黄嘌呤是白色结晶固体。它是咖啡因的衍生物，具有类似的生物活性。它在室温下具有良好的溶解性，可以在水、乙醇、丙酮等溶剂中溶解。
用途： 它具有类似咖啡因的兴奋效果，它常被添加到能量饮料、咖啡和其他饮品中，以增加人体的注意力和警觉性。
制法：
3-异丁基-1-甲基黄嘌呤可以通过将异丁烯基胺与甲基黄嘌呤进行硼氢化钠催化加成反应得到。具体的制备方法需要在合适的实验条件下进行。
安全信息：
使用3-异丁基-1-甲基黄嘌呤时应注意以下安全事项：
- 它是一种刺激性化学物质，应避免皮肤接触和吸入。
- 在使用过程中应佩戴适当的防护装备，如手套、防护眼镜和防护面罩。
- 废弃物应按照当地法规进行处置，不得随意丢弃。
最后更新：2024-04-09 21:04:16
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