MK-212(一盐酸盐),英文名:MK-212 HCl,CAS:61655-58-1,Description: MK-212 is a 5HT2C-receptor agonist. A dose-d

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61655-58-1 询问

MK-212(一盐酸盐)(MK-212 HCl)

CAS: 61655-58-1

化学式: C8H12Cl2N4

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中文名	MK-212(一盐酸盐)
英文名	MK-212 HCl
别名	MK-212(一盐酸盐) 2-氯-6-哌嗪吡嗪盐酸盐 2-氯-6-(哌嗪-1-基)吡嗪盐酸盐
英文别名	NSC 31732 MK-212 HCl MK-212 (monohydrochloride) 2-Chloro-6-(1-piperazinyl)-pyrazine hydrochloride 2-chloro-6-(piperazin-1-yl)pyrazine hydrochloride 2-chloro-6-(1-piperazinyl)pyrazine monohydrochloride
CAS	61655-58-1
EINECS	262-883-0
化学式	C8H12Cl2N4
分子量	235.11368
溶解度	DMSO: ≥ 20 mg/mL
存储条件	Inert atmosphere,2-8°C
外观	粉末
颜色	white to off-white
产品用途	Description: MK-212 is a 5HT2C-receptor agonist. A dose-dependent the effect of 5HT2C-receptor agonist MK-212 on mouse behavior was demonstrated. Intraperitoneal injection of MK-212 in high doses (0.5 and 1.0 mg/kg) increased blood level of corticosterone in mice and reduced their motor activity. In low doses of 0.1 and 0.2 mg/kg, the agonist reduced anxiety, but had no effect on motor activity. It is hypothesized that low doses of MK-212 exhibited anxiolytic activity in mice.
靶点	5-HT2C receptor agonist
危险品标志	T - 有毒物品
风险术语	25 - 吞食有毒。
安全术语	45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。
危险品运输编号	UN 2811 6.1 / PGIII
WGK Germany	3
参考资料 展开查看	1: Kozhevnikova LM, Mesitov MV, Moskovtsev AA. [Agonists of 5HT2C-receptors SCH 23390 and MK 212 incresase the force of rat aorta contraction in the presence of vasopressin and angiotensin II]. Patol Fiziol Eksp Ter. 2014 Oct-Dec;(4):17-29. Russian. PubMed PMID: 25980223. 2: Kuznetsova EG, Amstislavskaya TG, Bulygina VV, Tibeikina MA, Popova NK. Effect of 5HT2C-receptor agonist MK-212 on blood corticosterone level and behavior in mice. Bull Exp Biol Med. 2006 Nov;142(5):594-7. PubMed PMID: 17415471. 3: de Mello Cruz AP, Pinheiro G, Alves SH, Ferreira G, Mendes M, Faria L, Macedo CE, Motta V, Landeira-Fernandez J. Behavioral effects of systemically administered MK-212 are prevented by ritanserin microinfusion into the basolateral amygdala of rats exposed to the elevated plus-maze. Psychopharmacology (Berl). 2005 Nov;182(3):345-54. Epub 2005 Oct 19. PubMed PMID: 16133141. 4: Halford JC, Lawton CL, Blundell JE. The 5-HT2 receptor agonist MK-212 reduces food intake and increases resting but prevents the behavioural satiety sequence. Pharmacol Biochem Behav. 1997 Jan;56(1):41-6. PubMed PMID: 8981607.

61655-58-1 - 配置溶液浓度参考

	1mg	5mg	10mg
1 mM	4.253 ml	21.266 ml	42.533 ml
5 mM	0.851 ml	4.253 ml	8.507 ml
10 mM	0.425 ml	2.127 ml	4.253 ml
5 mM	0.085 ml	0.425 ml	0.851 ml

最后更新：2024-01-02 23:10:35