糖皮质激素信号通路PCR芯片Glucocorticoid Signaling PCR Array

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                       糖皮质激素信号通路PCR芯片可用于研究与糖皮质激素信号通路相关的84个基因的表达情况。The Human Glucocorticoid Signaling RT² Profiler PCR Array profiles the expression of 84 key genes involved in signaling initiated by the glucocorticoid receptor. Secreted by the adrenal cortex, glucocorticoid hormones affect several biological processes, from inhibiting inflammation to maintaining normal blood glucose levels and more. Signaling occurs when the glucocorticoid receptor binds the cell-permeable hormones, causing nuclear translocation, interaction with other co-transcription factors (indicating a role of crosstalk with other pathways), and the activation or repression of target gene expression. The therapeutic use of glucocorticoids (such as the commonly used prednisone, dexamethasone, or hydrocortisone) helps treat various disorders including allergies, asthma, autoimmune diseases, dermatitis, leukemia, lymphomas, and rheumatoid arthritis. Their immunosuppressant activity also helps prevent acute transplant rejection and graft-versus-host disease. Resistance and side-effects (such as the susceptibility to infection and inhibition of tissue repair processes) limit the long-term use of these drugs, but has spurred research into the development of safer glucocorticoid analogs. Examining glucocorticoid transcriptional responses could help provide a better understanding of their effects on biological processes in any target tissue. This array includes the glucocorticoid receptors and key co-transcription factors, but mostly target genes identified from studies simultaneously using both chromatin immunoprecipitation (ChIP) and gene expression in the two key responsive tissues: adipose and lung. A set of controls present on each array enables data analysis using the ΔΔCT method of relative quantification, assessment of reverse transcription performance, genomic DNA contamination, and PCR performance. Using real-time PCR, research studies can easily and reliably analyze the expression of a focused panel of genes involved in glucocorticoid signaling with this array.
Glucocorticoid Receptor & Cotranscription Factors: ATF4, CEBPA, CEBPB, CREB1, CREB3, CREB3L4, NR3C1, POU2F1, POU2F2, STAT5A, STAT5B.
Glucocorticoid Receptor Target Genes:
Glucose & Fatty Acid Metabolism: ASPH, GDPD1, GLUL, GOT1, H6PD, PDP1.
Cytokines & Chemokines: EDN1, IL10, IL1RN, IL6, IL6R, TNF.
Growth Factors: ANGPTL4, CTGF.
Extracellular Matrix: COL4A2, HAS2, LOX.
Cytoskeleton Regulation: PLEKHF1, RHOB, RHOJ, SNTA1.
Endocytosis & Exocytotsis: ANXA4, EHD3, MERTK, PLEKHF1.
Cell Surface Receptors: CALCR, GHRHR, PDGFRB, VLDLR.
Channels & Transporters: AQP1, SLC10A6, SLC19A2, SLC22A5.
Signal Transduction: BMPER, DIRAS2, DUSP1, NFKBIA, PIK3R1, PLD1, RASA3, RGS2, SESN1, SGK1, SPHK1, TNF, USP2.
Stress Responses: BCL6, DDIT4, PDCD7, SESN1, SGK1.
Transcription Factors: ARID5B, CEBPB, FOSL2, KLF13, KLF9, NFKBIA, TBL1XR1, TNFAIP3, TSC22D3, VDR, ZFP36, ZHX3.
Circadian Rhythm: PER1, PER2.
RNA Processing: ADARB1, AFF1, HNRPLL.
Protein Folding & Trafficking: FKBP5, LOX.
Metallothioneins: MT1E, MT2A.
Nucleotide Metabolism: AK2, AMPD3, XDH.
Others: CYB561, ERRFI1, SPSB1, USP54, ZNF281.
Up-Regulated in Adipose & Muscle: ADARB1, AFF1, AMPD3, ANXA4, ARID5B, ASPH, BMPER, DDIT4, DUSP1, EHD3, ERRFI1, FKBP5, GDPD1, GLUL, H6PD, HNRPLL, KLF13, LOX, MERTK, PDP1, PER1, PER2, PIK3R1, PLD1, PLEKHF1, RASA3, RGS2, RHOJ, SESN1, SGK1, SLC10A6, SNTA1, SPHK1, SPSB1, TBL1XR1, TSC22D3, USP2, USP54, VDR, VLDLR, XDH, ZFP36, ZHX3.
Up-Regulated in Muscle: CEBPB, COL4A2, CTGF, CYB561, DIRAS2, EDN1, KLF9.
Up-Regulated in Adipose: ANGPTL4, BCL6, FOSL2, NFKBIA, RHOB, SLC19A2, SLC22A5, TNFAIP3.
Down-Regulated in Adipose: AK2, DIRAS2, HAS2, PDGFRB.

糖皮质激素信号通路PCR芯片Glucocorticoid Signaling PCR Array,糖皮质激素信号通路PCR芯片Glucocorticoid Signaling PCR Array

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